Towards Personalized Cancer Medicine
CosmoCaixa, Barcelona, Spain

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     *  Abstract Deadline:
       19th March 2010


   Keynote Speaker:
   Nobel laureate J. Michael Bishop, MD, Professor and Director,
   The G.W Hooper Research Foundation, University of California, San

   Scientific Organizing Committee: José Baselga, MD, Vall d’Hebron
   University Hospital, Barcelona, Alison Farrell, PhD, Nature Medicine,
   San Francisco. Stephen H. Friend, MD, PhD, Sage Bionetworks, Seattle.
   Joan Massagué, PhD, Sloan-Kettering Institute, New York; Institute
   for Research in Biomedicine, Barcelona (Adjunct). Manuel Perucho, PhD,
   Institute of Predictive and Personalized Medicine of Cancer,
   Barcelona; the Burnham Institute for Medical Research, San Diego.
   Brian Pollok, PhD, Life Technologies, Carlsbad, Featured
   Presentations: James Allison, PhD, Memorial Sloan Kettering Cancer
   Center. Alan Ashworth, PhD Breakthrough Breast Cancer. Research Center
   Stephen B. Baylin, MD The Sidney Kimmel Comprehensive Cancer Center at
   Johns Hopkins. René Bernards, PhD The Netherlands Cancer Institute.
   Lynda Chin, MD Harvard Medical School. Arul Chinnaiyan, MD University
   of Michigan. Hans Clevers, MD, PhD Netherlands Institute of
   Developmental Biology. Carlo Croce, MD Ohio State University.
   Napoleone Ferrara, MD Genentech, Inc. Gary Gilliland, MD, PhD Merck
   Research Laboratories. Todd Golub, MD Broad Institute. Joe W. Gray,
   PhD Lawrence Berkeley National Laboratory. Sam Hanash, MD, PhD Fred
   Hutchinson Cancer Research Center. William G. Kaelin Jr., MD Harvard
   Medical School. John McPherson, PhD Ontario Institute for Cancer
   Research. Yusuke Nakamura, MD, PhD RIKEN Yokohama Institute. Quyen T.
   Nguyen, MD, PhD University of California San Diego. Klaus Pantel, MD,
   PhD University Medical Center Hamburg-Eppendorf. Charles Perou, PhD
   University of North Carolina (Chapel Hill). Judith Sebolt-Leopold, PhD
   Oncovera Therapeutics. William R. Sellers, MD Novartis Institute of
   Biomedical Research. Jeff Settleman, PhD Massachusetts General
   Hospital Cancer Center. Ian Tomlinson, PhD The Wellcome Trust Centre
   for Human Genetics, University of Oxford. Laura van’t Veer, PhD The
   Netherlands Cancer Institute. James Watters, PhD Merck Research
   Laboratories. Featuring keynote address by Nobel Laureate J. Michael
   Bishop, MD, this 3-day conference will explore cancer as an
   individualized problem and address the impact of recent advances in
   cancer biology, genetics, tumor profiling, and medical technology in
   the personalization of cancer predisposition, diagnosis, prognosis,
   treatment, and therapy development.

Schedule of Presentations:

Wednesday, May 19, 2010
07:45:00 Registration and Breakfast
08:45:00 Welcome Address
08:55:00 Keynote Address
09:00:00 The Cancer Genome and Therapeutics J. Michael Bishop
09:55:00 SESSION I: Biology (Processes Leading to Cancer) Joan Massagué
10:00:00 Wnt, Lgr5 Stem Cells and Colon Cancer Hans Clevers
10:30:00 New Cancer Targets Emerging From Studies of the von Hippel-Lindau Tumor Suppressor Protein William G Kaelin
11:00:00 Coffee Break
11:30:00 Role of the Microenvironment in VEGF-Independent Angiogenesis Napoleone Ferrara
12:00:00 Deconstructing Metastasis Joan Massagué
12:30:00 2 investigators selected from abstracts
13:00:00 Lunch and Poster Session
14:55:00 SESSION II: Genetics and Epigenetics (Cancer Susceptibility) Manuel Perucho
15:00:00 Therapeutic Cancer Vaccine Development Yusuke NAKAMURA
15:30:00 Susceptibility to the Common Cancers Ian Tomlinson
16:00:00 2 investigators selected from abstracts
16:30:00 Coffee Break
17:00:00 Genetics and Epigenetics of Colon Cancer | Manuel Perucho Manuel Perucho
17:30:00 Genetics and Epigenetics of Colon Cancer | Stephen B. Baylin Stephen B Baylin
18:00:00 End of Day 1
Thursday, May 20, 2010
07:30:00 Registration and Breakfast
08:25:00 SESSION III: Oncogenomics and Tumor Profiling Lynda Chin
08:30:00 Genomic Views of Cancer Todd Golub
09:00:00 Gene Fusion Discovery in Cancer Arul M Chinnaiyan
09:30:00 Subsets, Specific Therapies in Breast Cancer Joe W Gray
10:00:00 2 investigators selected from abstracts
10:30:00 Coffee Break
11:00:00 Finding Biomarkers of Drug Responsivenes Through Functional Genetic Screens René Bernards
11:30:00 Causes and Consequences of microRNA Dysregulation in Cancer Carlo Croce
12:00:00 Functionalizing the Cancer Genome Lynda Chin
12:30:00 Lunch and Poster Session
14:00:00 SESSION IV: Biomarkers for Prognosis/Response: Impact on Clinical Trials Stephen H Friend
14:30:00 Integrative Genomic Models of Disease, Use of Contributor Networks Stephen H Friend
15:00:00 TBD
15:30:00 From Genomic Landscapes to Personalized Cancer management - Is There a Roadmap? Carlos Caldas
16:00:00 2 investigators selected from abstracts
16:30:00 Coffee Break
17:00:00 Molelcular Portraits of Breast Tumors | Charles M. Perou Charles Perou
17:30:00 Molelcular Portraits of Breast Tumors | Laura van’t Veer Laura van’t Veer
18:00:00 Molecular Profiling of Pre-Clinical and Clinical Models: Informing the Development of Rational Combinations James Watters
18:30:00 Reception
20:30:00 End of Day 2
Friday, May 21, 2010
07:30:00 Registration and Breakfast
08:00:00 SESSION V: Targeted Therapies I José Baselga
08:30:00 Synthetic Lethal Approaches to Cancer Therapy Alan Ashworth
09:00:00 Target and Drug Discovery in Oncology: The Right Drug for the Right Patient D. Gary Gilliland
09:30:00 Targeting the PI3K Pathway José Baselga
10:00:00 2 investigators selected from abstracts
10:30:00 Coffee Break
10:55:00 Technology Workshop
11:00:00 Introductory Overview Brian Pollok
11:10:00 Circulating Tumor Cells Klaus Pantel
11:30:00 Surgery with Molecular Navigation T Nguyen
11:50:00 Next-Generation Sequencing Technologies John McPherson
12:10:00 Patient Tumor Genomics Michèl Schummer
12:30:00 Lunch + Poster Session
14:30:00 PANEL DISCUSSION Alison Farrell, William R Sellers, Stephen H Friend, José Baselga, Lynda Chin
15:00:00 SESSION VI: Targeted Therapies II Alison Farrell
15:30:00 2 investigators selected from abstracts
16:00:00 The Discovery and Application of Cancer Therapeutics in the Genomic Era William R Sellers
16:30:00 Is MEK a Valid Target for the Treatment of Pancreatic Cancer? Judith Sebolt-Leopold
17:00:00 Immune Checkpoint Blockade in Cancer Therapy James P Allison
17:30:00 Closing Remarks Joan Massagué
18:00:00 End of Conference
3D Tissue Models
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