6th Annual Meeting of the Oligonucleotide Therapeutics Society
Laguna Cliffs Resort
33282 Golden Lantern St
Dana Point, California

   Nobel-prize winner Andrew Fire

   This October, leading experts in oligonucleotide research will come
   together for the Sixth Annual Meeting of the Oligonucleotide
   Therapeutics Society. Nobel-prize winner Andrew Fire will deliver the
   keynote lecture of this three and a half day meeting, which will
   feature the latest developments from various oligonucelotide-based
   disciplines including antisense, siRNA, immunodulatory, aptamers and
   micro/non-coding RNA research. This unique meeting offers an exciting
   opportunity to foster strong synergies between different areas of
   oligonucleotide research.

   33282 Golden Lantern St, Dana Point, CA, Dana Point, , United States

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Schedule of Presentations:

Wednesday, October 20, 2010
12:00:00 Registration & Poster Set-Up
14:00:00 Welcome and Introductory Remarks Alan Gewirtz
14:10:00 Session I : Genome-wide definition of the human transcriptome and posttranscriptional and posttranslational regulation of protein abundance Thomas Tuschl
14:15:00 Seeing the forest from the trees: ab initio reconstruction of mammalian transcriptomes from RNAseq Aviv Regev
14:45:00 Control of 3´UTR length by alternative cleavage and polyadenylation and its role in human cancer Christine Mayr
15:15:00 Correlation of protein and transcript abundance and the identification of posttranscriptionally and posttranslationally regulated genes by quantitative proteomics Shao-En Ong
15:45:00 Refreshment Break
16:15:00 Global measurements of translation by ribosome profiling Nick Ingolia
16:45:00 Combinatorial mRNA Control Jack Keene
17:15:00 Biochemical and deep-sequencing based approaches to identify posttranscriptional regulatory networks Thomas Tuschl
17:45:00 Welcome Reception
19:30:00 End Day 1
Thursday, October 21, 2010
07:00:00 Registration, Continental Breakfast, Poster set-up
08:00:00 Keynote Lecture : "Generic" architecture in biological surveillance and regulation Andrew Fire
09:00:00 Session II: Novel Approaches for RNA Targeting David Corey
09:05:00 Role of Intergenic Noncoding RNAs John Rinn
09:30:00 Function of Noncoding Transcripts Claes Wahlestedt
10:00:00 Refreshment Break
10:30:00 Conformationally Constrained Oligonucleotides Eric Swayze
11:00:00 Steric block PNA and PMO oligonucleotides and their peptide conjugates for exon skipping and microRNA inhibition Mike Gait
11:30:00 Session III: Two Short (15 min) Abstract Talks Arthur M. Krieg
12:00:00 Lunch and Poster Viewing
13:30:00 Session IV: RISC-Based Mechanisms Anastasia Khvorova
13:35:00 Dissecting RISC function through chemical modification tolerance Muthiah Manoharan
14:00:00 siRNA delivery – The 800 Pound Gorilla Steven F. Dowdy
14:30:00 Preclinical Development of RNA Therapeutics Michael Flanagan
15:00:00 Refreshment Break
15:30:00 sd-rxRNA – New class of RNAi compounds: Structure, mechanisms of uptake, preclinical development Anastasia Khvorova
16:00:00 Knocking down barriers: Advances in RNAi delivery Daniel G Anderson
16:30:00 Session V: Oligonucleotides and Stem Cells Dieter C Gruenert
16:35:00 The application of activating dsRNA (RNAa) on gene expression in iPS cells Long-Cheng Li
17:00:00 micro RNAs in stem cells Frank Slack
17:30:00 Gene targeting in pluri potent cells Giuseppe Novelli
18:00:00 End Day 2
Friday, October 22, 2010
07:00:00 Continental Breakfast
08:00:00 Session VI: RNaseH-Based Mechanisms Brett Monia
08:05:00 Enzymology of RNaseH Robert J. Crouch
08:30:00 Influence of RNA Structure on Oligonucleotide Binding David Mathews
09:00:00 RNaseH-Dependent Antisense Approaches for Huntington Disease Don W Cleveland
09:30:00 Refreshment Break
10:00:00 Oligonucleotide Therapeutics: Small is Beautiful Henrik Orum
10:30:00 Reduction in Survivin Levels in Cancer Patients with LY2181308 Michael Lahn
11:00:00 Session VII: Four Short (15 min) Abstract Talks Hermona Soreq
12:00:00 Lunch and Poster Viewing
13:30:00 Session VIII: Oligonucleotide Applications: Non-coding and microRNAs Peter Linsley
13:35:00 microRNAs: Metabolic regulators and therapeutic targets Stoffel Markus
14:00:00 microRNA mimics and diagnostics Lee P. Lim
14:30:00 microRNAs in cardiovascular diseases Stefanie Dimmeler
15:00:00 Silencing of microRNA families by seed-targeting tiny LNAs Sakari Kauppinen
15:30:00 Refreshment Break
16:00:00 Session IX: Immunomodulatory Oligonucleotides Gunther Hartmann
16:05:00 Intracellular DNA recognition by the innate immune system Veit Hornung
16:30:00 Dicer-mediated antiviral responses in mammals Hiroki Kato
17:00:00 Non-self discrimination of viral RNA: Lessons from hepatitis C virus
17:30:00 Rational design of bifunctional siRNA Bryan R Williams
18:00:00 Poster Reception
19:30:00 End of Day 3
Saturday, October 23, 2010
07:00:00 Continental Breakfast
08:00:00 Session X: Splicing Applications Frank Bennett
08:05:00 Regulation of Splicing Kristin W. Lynch
08:30:00 Antisense Approaches for Treating Myotonic Dystrophy Charles Thornton
09:00:00 Progress in exon-skipping, systemic delivery trial of AVI-4658 for treatment of Duchenne muscular dystrophy Ryszard Kole
09:30:00 Correcting Causal Splicing Defects in Spinal Muscular Atrophy Marco Passini
10:00:00 Refreshment Break
10:30:00 Session XI: Aptamers Bruce A. Sullenger
10:35:00 Aptamer-siRNA conjugates and Bi-Functional Agonistic Aptamers for Cancer Immunotherapy Eli Gilboa
11:00:00 Advancement in Cell-Based SELEX Vittoria de Franciscis
11:30:00 Aptamers for the Treatment of Viral Pathogenesis Donald Burke
12:00:00 Lunch
13:00:00 Session XII: Preclinical Applications John Rossi
13:05:00 Development of DsiRNAs Against Classic ‘Undruggable’ Targets in Oncology Bob Brown
13:30:00 Antisense Approaches for Treating Thrombosis Brett Monia
14:00:00 Targeting microRNAs for Therapeutics Peter Linsley
14:30:00 Using Nucleic Acid Binding Polymers to Control Aptamers and Inflammation Bruce A. Sullenger
15:00:00 Refreshment Break
15:30:00 Session XIII: Clinical Applications Pam Pavco
15:35:00 Development of SPC3649 for HCV Art Levin
16:00:00 Clinical Development of OGX427 and OGX011 for Cancer Kim Chi
16:30:00 Pharmacology & Clinical Development of AIR645; an Inhaled IL-4Rα Antisense Inhibitor Michael Hodges
17:00:00 Integrating Preclinical and Clinical Experience in the Development of Next Generation siRNA Products Ian MacLachlan
17:30:00 Closing Remarks Alan Gewirtz
18:00:00 End of Conference
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