The Ubiquitin Drug Discovery & Diagnostics Conference
Four Seasons Hotel, Philadelphia, PA
Four Seasons Hotel
Philadelphia, Pennsylvania,


   The Ubiquitin Drug Discovery & Diagnostics Conference

   August 23-25, 2010
   Philadelphia, PA

   Contact Information :

   Jennifer Minicozzi
   Conference Coordinator
   610-644-0585 ext 300

   Varsha Luthra
   Conference Director
   610-644-0585 ext 325

Schedule of Presentations:

Monday, August 23, 2010
13:00:00 Pre-Conference Workshop
Tuesday, August 24, 2010
07:00:00 Continental Breakfast (Ballroom Foyer)
08:15:00 Welcome by the Conference Chair Joseph Bolen
08:30:00 Keynote Address Alfred L. Goldberg
08:55:00 Session 1: Understanding the Ubiquitome
09:00:00 Assembly and Structure of the Eukaryotic Proteasome Mark Hochstrasser
09:25:00 Proteomic and informatic approaches in the study of the Ubiquitin Pathway Wade Harper
09:50:00 Selected Talk from Abstract
10:05:00 Coffee Break
10:40:00 Modulation of prion formation by the ubiquitin proteasome system and actin cytoskeleton Keith Wilkinson
11:05:00 TBA Christopher P. Austin
11:30:00 Selected Talk from Abstract
11:45:00 Selected Talk from Abstract
12:00:00 Lunch in the Swann Restaurant
13:25:00 Session 2: Targeting Deubiquitylases for Therapy
13:30:00 Enzyme regulatory mechanisms of USP7 James Ernst
13:55:00 Ubiquitin Specific Proteases as novel drug targets – A case study Jonathan D. Wrigley
14:20:00 Discovery of Ubiquitin Isopeptidase Inhibitors Ben Nicholson
14:45:00 Selected Talk from Submitted Abstracts
15:00:00 Coffee Break
15:30:00 TBA
15:55:00 Specificity of DUB inhibitors in cells profiled by activity-based chemical proteomics Benedikt M. Kessler
16:20:00 Inhibition of proteasomal deubiquitinating enzyme Usp14 Daniel Finley
16:45:00 Selected Talk from Submitted Abstracts
17:00:00 Business Roundtable Discussion Groups
18:00:00 Poster Viewing and Cocktail Hour
19:30:00 Dinner in the Ballroom Rounds
Wednesday, August 25, 2010
07:00:00 Continental Breakfast in the Ballroom Foyer
08:25:00 Session 3: Targeting E3 ligases for therapy
08:30:00 Novel Mechanism-based E1 Inhibitors in Drug Discovery Jesse Chen
08:55:00 Structural Insights and Functional Complexity of E2 - RING Finger E3 Interactions Allan Weissman
09:20:00 TBA
09:45:00 Selected Talk from Abstract
10:00:00 Coffee Break
10:40:00 Identification of E3 Ligase Inhibitors Using a Novel Assay Michael Eddins
11:05:00 TBA Paul Andrews
11:30:00 Selected Talk from Submitted Abstracts
11:45:00 Selected Talk from Submitted Abstracts
12:00:00 Lunch in Swann Restaurant
13:25:00 Session 4: Ubiquitin Pathway Inhibitors in the Clinic
13:30:00 Targeting Protein Degradatation as a Therapeutic Strategy in Myeloma Kenneth C Anderson
13:55:00 TBA
14:20:00 ONX0912: an in vitro and in vivo evaluation of an orally bioavailable proteasome inhibitor Shirin Kapur
14:45:00 Selected Talk from Submitted Abstracts
15:00:00 Coffee Break
15:30:00 Role of proteosome inhibition in organ transplantation E Steve Woodle
15:55:00 Inhibition of NEDD8-activating enzyme for cancer treatment: Preclinical validation to clinical application of MLN4924 Peter G Smith
16:20:00 TBA Dan Vogl
16:45:00 Selected Talk from Submitted Abstracts
17:00:00 Conference Concludes
3D Tissue Models
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