3D Tissue Models
Fourteenth Annual Choosing, Designing, and Optimizing Hosts and Platforms
Hotel Del Coronado
1500 Orange Ave.
Coronado, California
Great strides have been made in the expression of proteins for biotherapeutics; however, with these strides have come new hurdles. Higher-throughput expression
and purification, as well as more flexible expression systems and techniques are in even greater demand now to support the needs of the research pipeline.
This meeting explores the newest data and innovations relating to the expression and characterization of proteins for biological understanding and therapeutics, as
well as strategies to make the eventual expression of these proteins more effective, efficient and trouble-free. Attention is given to new hosts and platforms, as
well as how to select, engineer and optimize these hosts

Schedule of Presentations:

Tuesday, January 11, 2011
13:30:00 Conference Registration
14:00:00 BuzZ Session A | Interactive participation leads to problem-solving solutions and future collaborations around focused topics.
14:45:00 Refreshment Break | Exhibit and Poster Viewing
15:15:00 Poster Awards | Exhibit Hall
15:30:00 BuzZ Session B | Interactive participation leads to problem-solving solutions and future collaborations around focused topics.
16:15:00 End of Day
Wednesday, January 12, 2011
07:00:00 Conference Registration
07:30:00 Breakfast Presentation | Coffee
08:15:00 Chairperson’s Opening Remarks M. Raafat El-Gewely
08:20:00 Keynote Presentation | Significant Enhanced Expression and Solubility of Human Proteins in Escherichia coli by Fusion with Protein S from Myxococcus xanthus Masayori Inouye
09:00:00 Structural Insights into Bacteriophage Protein Complexes Revealed by Hybrid Methods David Veesler
09:30:00 Secretion and Proteolysis of Heterologous Proteins Fused to the Escherichia coli Maltose Binding Protein in Pichia pastoris Geoffrey Lin-Cereghino
10:00:00 Coffee Break | Exhibit and Poster Viewing
10:45:00 Use of the Design-of-Experiments Approach for the Development of a Refolding Technology for Progenipoietin-1, a Recombinant Human Cytokine Fusion Protein from Escherichia coli Inclusion Bodies Denis M. Boyle
11:15:00 Overcoming Bottle-Neck Problems in Producing Recombinant Therapeutic Proteins at Early Stages and the Potential Impact of Novel Conformases/Foldases on the Field M. Raafat El-Gewely
11:45:00 Sponsored Presentation
12:15:00 Close of Morning Session
12:30:00 Luncheon Presentation
13:55:00 Optimizing and Automating
14:00:00 Chairperson’s Remarks Dominic Esposito
14:05:00 A Toolbox for High-Throughput Parallel Clone Construction for Protein Expression Optimization in Multiple Host Systems Dominic Esposito
14:35:00 When Proteins Misbehave, Try a Little Pressure: Refolding Pol nu Robert M. Petrovich
15:05:00 Prediction of Protein Solubility in Escherichia coli Using Logistic Regression Roger G. Harrison
15:35:00 Human In Vitro Translation Systems for Rapid Production of Functional Proteins Peter A. Bell
15:50:00 Networking Refreshment Break
16:30:00 Development of a Fully Automated, Miniaturized Bioreactor System for Optimization of Protein Production Processes Jacques Bellalou
17:00:00 High-Throughput Protein Expression Using an Improved Drosophila S2 Expression System Wian de Jongh
17:30:00 Reception | Exhibit Hall
18:30:00 Close of Day
Thursday, January 13, 2011
07:30:00 Breakfast Presentation | Coffee
08:10:00 Conquering Mammalian Expression and Membrane Proteins
08:15:00 Chairperson’s Opening Remarks Christopher Mehlin
08:20:00 Fusion Partners as a Tool for the Expression of Difficult Proteins in Mammalian Cells Christopher Mehlin
08:50:00 Increasing the Production of Biologics through the Induction of Growth Arrest in Mammalian Cell Systems Kevin Sunley
09:20:00 Expression and Purification of the Membrane Protein p7 from HCV Stanley J. Opella
09:50:00 High-Throuput Protein Purification for Multiplexed Assays Walter Tian
10:05:00 Coffee Break | Exhibit and Poster Viewing
10:30:00 Poster Awards | Exhibit Hall
10:45:00 Quality Optimization of Cell-Free Expressed Membrane Proteins: Characterization of the Human Endothelin Receptor Friederike Junge
11:15:00 High Yield Cell-Free Expression System Based on Leishmania tarentolae Kirill Alexandrov
11:45:00 Triple Light Chain Antibodies: Factors that Influence its Formation in Cell Culture Natalia Gomez
12:15:00 Close of Morning Session
12:30:00 Luncheon Presentations | or Lunch on Your Own
13:30:00 End of Conference
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