EMBO|EMBL Symposia:Structure and Dynamics of Protein Networks
Advanced Training Center, EMBL Heidelberg
Meyerhofstr. 1
Heidelberg, Baden Württemberg
   Modern scientists access an unprecedented level of knowledge on the
   basic components making up living systems; an ever-growing number of
   methods are currently available that allow parallel measurements of
   the behaviour and properties of all individual cellular components.
   Despite these spectacular progresses we still largely don’t understand
   how cellular components work collectively and achieve biological
   function. Understanding the molecular mechanisms of biological
   function largely relies on the systematic charting of the dynamics
   interactions taking place between the various components of living
   cells. Recent “ OMICS � technologies contribute large biological
   networks covering entire proteomes. These networks are generally
   static as they fail to capture spatial and temporal dimensions that
   represent essential properties of living systems. Mechanistic and
   dynamic insights often come from focused smaller-scale approaches,
   such as those used in structural biology, biophysics or cell biology.
   The meeting will bring together leading scientists from the “ OMICS �
   field with leading structural and cell biologists, for the main
   purpose of discussing scientific issues arising at the interface of
   these complementary fields. The general aim of the symposium is to
   explore the possible synergisms and cross-talk between the large-scale
   and classical approaches to biological networks and review/investigate
   possible avenue to more generally populate current networks with
   dynamics and mechanistic insights that will ensure high levels of
   biological understanding and contributes deciphering fundamental

   Sessions: Signalling Networks and Circuits – Information networks
   Structure-Based Networks Multiscale analysis and integration of
   Cellular Networks From Quantitative Network to Cell Biology – Cell
   Biology of Protein Networks

Schedule of Presentations:

Thursday, October 13, 2011
15:00:00 Arrival & Registration
17:15:00 Welcome
17:30:00 Keynote Session | Promiscuous liaisons: functional interactions of intrinsically disordered proteins in signaling networks
18:30:00 Session 1 | Signalling Networks and Circuits Information networks Garry P Nolan, Philippe Bastiaens
18:45:00 Life in the balance: variability in cellular responses to death-inducing ligands"
20:00:00 Dinner
21:00:00 Roof Top Lounge
Friday, October 14, 2011
09:00:00 Session 1 (cont) - Signalling Networks and Circuits – Information networks Giulio Superti-Furga
09:15:00 Dynamics of clathrin-mediated endocytosi in yeast Marko Kaksonen
09:30:00 A map of non-vesicular lipid transport in Saccharomyces cerevisiae uncovered using tandem affinity purification-tag strains
10:15:00 Coffee Break
10:45:00 Session 1 (cont) - Signalling Networks and Circuits – Information networks
11:00:00 A systematic screen for protein–lipid interactions in Saccharomyces cerevisiae Anne-Claude Gavin
11:15:00 Mitochondrial protein biogenesis is regulated by cytosolic kinases
11:30:00 Systematic study of the role of human RhoGAPs/GEFs in the spatio-temporal control of Rho signaling specificity
11:45:00 Lunch
14:00:00 Session 2 - Structure-Based Networks
14:00:00 A network medicine approach to human disease Patrick Aloy
14:15:00 An evolutionary method for distinguishing biological interfaces from crystal contacts: applications to structure-based networks
15:45:00 Coffee Break
16:15:00 Session 2 - Structure-Based Networks
16:30:00 Design and engineering ofpProteins, interactions and networks Tanja Kortemme
16:45:00 Cellular PTMs and Conformational Plasticity of Protein Network Hubs" Guillermo Montoya, CNIO - "Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin
18:00:00 Poster Session 1
20:00:00 Dinner
21:00:00 Roof Top Lounge
Saturday, October 15, 2011
09:00:00 Session 3 | From Quantitative Network to Cell Biology – Cell Biology of Protein Networks
09:30:00 Anatomy of a kinetochore: Building a microtubule attachment site" François Nédélec, EMBL - "Effective spatial organization from simple cytoskeletal elements Victor Sourjik
10:15:00 Coffee Break
10:45:00 Session 3 (cont) - From Quantitative Network to Cell Biology – Cell Biology of Protein Networks Marino Zerial
11:00:00 Systems analysis of endosomal transport and signalling Jussi Taipale
11:15:00 nformation processing in the signaling network of B. subtilis
12:00:00 Lunch
14:00:00 Session 3 - From Quantitative Network to Cell Biology – Cell Biology of Protein Networks Lucas Pelkmans
14:15:00 Charting the human kinome interactome
14:45:00 Coffee Break
15:15:00 Keynote Session | Dynamics of endocytosis T. Kirchhausen
16:15:00 Keynote Session | Post-translational modifications in the assembly of regulatory protein networks Tony Pawson
17:15:00 Poster Session 2
19:15:00 Dinner & Party
Sunday, October 16, 2011
11:00:00 Session 4 - Multiscale analysis and integration of Cellular Networks Ben Lehner
11:05:00 Dynamics of genetic interaction networks Ben Lehner
11:30:00 Essential elastic and shape parameters govern the dynamics and energetics of dynamin-mediated membrane fission Aurelien Roux
11:45:00 All in vitro approach to deciphering assembly of multisubunit protein complexes
12:00:00 Mapping of signaling events during collective life formation
12:30:00 Closing Remarks
3D Tissue Models
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