RNAi, miRNA & siRNA
Copthorne Tara Hotel
Scarsdale Place, Kensington, London, W8 5SR, United Kingdom
London, United Kingdom
SMi is proud to present its 6th conference on RNAi, miRNA and siRNA which shall tackle some of the most prominent issues that stand in the way of the successful harnessing of the vast potential that the process possesses. RNAi is still a new and exciting area of pharmaceutical development, however significant progress is required in certain areas, in achieving successful targeted delivery and tackling off targeting as two examples.

This conference will display some of the most promising results achieved; from structural determination through to specific therapeutic applications, clinical trial considerations and negotiating the regulatory minefield, attendees can be sure to expect an invaluable learning and networking experience.

    * RNA-based therapeutics
    * siRNA and oligoneucleotide delivery
    * The effect of pharma cuts on RNAi
    * miRNA in cardiovascular and immunology
    * Bioinformatics and computational support
    * Clinical trials and regulatory considerations
    * Epigenetics 

Schedule of Presentations:

Monday, June 27, 2011
08:30:00 Registration & Coffee
09:00:00 First Chair's Opening Remarks Dmitry Samarsky
09:10:00 Single stranded antisense - today’s situation and the future’s potential Troels Koch,
09:45:00 RNAi | Developing a New Therapeutic Platform Rachel Meyers
10:20:00 Opportunities and Challenges in siRNA Therapeutics Development Laura Sepp-Lorenzino
10:55:00 Morning Coffee
11:15:00 PANNEL DISCUSSION | The effect of pharma cuts on the further development and commercialisation of RNAi technologies Gary Carter, Emma Hickman, Troels Koch,, Dmitry Samarsky, Laura Sepp-Lorenzino
12:00:00 Guanidino modified siRNAs and EPR for structure determination Joachim Engels
12:35:00 Overcoming a key challenge of RNAi Therapeutics | Effective Systemic Delivery of siRNA in Humans Christopher Anzalone
13:10:00 Networking Lunch
14:10:00 Second Chair's Opening Remarks Attila A. Seyhan
14:20:00 sd-rxRNA™ – New class of RNAi compounds | Chemistry, in vivo efficacy and preclinical development Dmitry Samarsky
14:55:00 Delivery and therapeutic potential of naked (non-formulated) siRNAs (local and systemic administrations) Elena Feinstein
15:30:00 Micellar technologies for targeted gene silencing Damon Smith
16:10:00 Afternoon Tea
16:30:00 Pulmonary delivery of siRNA - Prospects for therapeutic intervention in respiratory disease Emma Hickman
17:05:00 Endosomolytic PepFect peptides for nucleic acid delivery Samir EL-Andaloussi
17:40:00 Manufacture and control of oligonucleotides – a new challenge for CMC Mike Webb
18:15:00 Second Chair’s Closing Remarks and Close of Day One Attila A. Seyhan
Tuesday, June 28, 2011
08:30:00 Registration & Coffee
09:00:00 First Chair's Opening Remarks Sterghios Moschos, Thomas Thum
09:10:00 Role of miRNAs in angiogenesis - from mechansims to therapeutic apporaches Jan Fiedler, Thomas Thum
09:45:00 Strategies for inhibiting the miRNA pathway Petr Svoboda
10:20:00 Role of miRNAs and long intergenic non-coding RNAs (lincRNAs) in respiratory and inflammatory disease Eleni Tsitsiou
10:55:00 Morning Coffee
11:15:00 The miR-155/PU.1 axis regulates B cell function Elena Vigorito
11:50:00 IP and Oligonucleotides Lorna Brazell,
12:25:00 TGF-ß gene silencing: experiences with competent authorities/regulatory bodies and clinical trials Karl-Hermann Schlingensiepen
13:00:00 Networking Lunch
14:00:00 Small RNAs as triggers for epigenetic control of gene expression John Rossi
14:20:00 PANNEL DISCUSSION | Epigenetics in RNAi Sterghios Moschos, John Rossi, Petr Svoboda
15:00:00 Afternoon Tea
15:20:00 GeneICE II - The Next Generation Mark Eccleston
15:55:00 Computational support of potential RNAi therapeutics Paul Wilson
16:30:00 RNA interference as a research and therapeutic tool…Has its time come? Attila A. Seyhan
17:05:00 Second Chair’s Closing Remarks and Close of Day Two Sterghios Moschos
3D Tissue Models
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