New Horizons in Cancer Research: Biology to Prevention to Therapy
The Leela Kempinski Gurgaon
Ambience Island, National Highway - 8 Gurgaon District, Haryana 122002 0124 4771234
Gurgaon, Delhi (NCR), India
India is a vibrant center for scientific research and clinical care, making it an outstanding site for the AACR international conference which will be held from December 13–16, 2011, in Delhi. A large, broadly focused meeting, New Horizons in Cancer Research: Biology to Prevention to Therapy will center on translational cancer research, drawing on the latest trends and discoveries in the early detection, prevention, and treatment of cancer. The conference will be structured to appeal to a broad spectrum of cancer researchers and clinicians. With a focus on advances in tumor biology, cancer genetics, molecular epidemiology, and novel therapeutics, the conference will pay particular attention to some of the most common cancers that occur in India, including head and neck, cervical, lung, and breast cancers.
The planning and execution of this meeting will be a collaborative effort involving a number of the world’s leading cancer researchers and clinicians. Both the Program Committee and the Organizing Committee are comprised of leaders in cancer research and care from both India and the United States; including conference Chairperson Dr. Anil K. Rustgi, chief of gastroenterology and T. Grier Miller professor of medicine and genetics at the Abramson Cancer Center of the University of Pennsylvania in Philadelphia, Pennsylvania. Dr. Rustgi is joined by an esteemed group of Co-Chairpersons including Dr. Rajendra A. Badwe, director, Tata Memorial Center in Mumbai, India; Dr. Raymond N. DuBois, provost and executive vice president, University of Texas MD Anderson Cancer Center in Houston, Texas; Dr. Judy E. Garber, director, Cancer Genetics and Prevention Center, Dana-Farber Cancer Institute in Boston, Massachusetts; Dr. Lalit Kumar, professor of medical oncology, All India Institute of Medical Sciences, Institute of Rotary Cancer Hospital in New Delhi, India; Dr. Matthew L. Meyerson, professor of pathology, Dana-Farber Cancer Institute in Boston, Massachusetts; and Dr. Annapoorni Rangarajan, assistant professor, Indian Institute of Science, Department of Molecular Reproduction, Development and Genetics in Bangalore, India.

A robust program is being developed, which will provide significant value to those attending the conference. Conference attendance will be drawn from the academic research and clinical community, as well as industry. As such, New Horizons in Cancer Research will serve as a dynamic platform for the advancement of cancer science and care, and for the establishment of new collaborations on an international scale. We are confident that this meeting will be fertile ground for the exchange of information, ideas, and resources.

Schedule of Presentations:

Tuesday, December 13, 2011
11:30:00 Current and future prospects for HPV vaccination Douglas R. Lowy
12:00:00 Opening Session
12:05:00 Welcome and Opening Remarks Judy Garber, Margaret Foti, Anil K Rustgi
12:10:00 Keynote Presentations
12:15:00 The state of the science in India
13:30:00 Break
13:45:00 Concurrent Sessions 1-2
13:50:00 Concurrent Session 1 | Shared Cyberinfrastructure for Cancer Research and Treatment
13:55:00 Global cancer grid: Vision and reality
14:00:00 Single cell informatics: Applications in stem cells and cancer
14:05:00 caBRAF: A caBIG-BRAF coaction for cancer bioinformatics
14:10:00 Indo-US partnership to accelerate botanicals and biologics drug development for cancer chemoprevention: In silico drug development model
14:15:00 Discussion
14:20:00 Concurrent Session 2 | Pancreatic Cancer Pramod Garg
14:25:00 Epidemiology, risk factors, and diagnosis of pancreatic cancer Pramod Garg
14:25:00 Molecular pathogenesis of pancreatic cancer and precursor lesions: Lessons from mice and men
14:30:00 Minnelide: A novel therapy for pancreatic cancer
14:45:00 Discussion Christopher Heeschen
15:20:00 Break
15:35:00 Concurrent Sessions 3-4
15:40:00 Concurrent Session 3 | Lung Cancer Matthew L. Meyerson
15:45:00 Somatic genome alterations in human lung cancers Matthew L. Meyerson
15:50:00 Clinical implications of genome sequencing in lung cancer Ramaswamy Govindan
15:55:00 Genomic medicine: Therapeutic opportunities for lung cancer in India
16:00:00 Methylation events in lung cancer: whole genome explorations of paired tumor and non-tumor clinical samples
16:05:00 Discussion
16:10:00 Concurrent Session 4 | Cancer Genetics Curtis C. Harris
16:15:00 Inflammation and cancer: Interweaving microRNA, innate immune, and p53 networks Curtis C. Harris
16:20:00 Nuclear organization: Effect of chromosome dosage? K Sengupta
16:25:00 Mechanism of chromosomal translocations in leukemia and lymphoma
17:20:00 Session 1 | A Role of Natural Products in the Discovery of Antitumor Drugs such as Taxol Susan Band Horwitz
17:35:00 Session 2 | Microenvironment in Hematological Malignancies Varsha Gandhi
18:20:00 Day in Review Anil K Rustgi, Pramod Garg, Curtis C. Harris, Matthew L. Meyerson
18:45:00 Opening Reception
Wednesday, December 14, 2011
09:25:00 Panel Discussion 1 | Drug Development and Clinical Trials in India Lalit Kumar
09:30:00 Break
09:50:00 Plenary Session 1 | Cancer Genomics Rajiv Sarin
09:55:00 Novel, founder, and recurrent germline mutations in high-penetrance cancer genes in South Asians Rajiv Sarin
10:00:00 Genomic alterations in gingivobuccal cancer: Results from whole-exome resequencing Sadhan Majumder
10:05:00 Interrogating the architecture of cancer genomes Peter Campbell
10:10:00 Exploiting tumour suppressor mechanisms that control genome stability in new approaches to cancer therapy Ashok R. Venkitaraman
10:15:00 Genome and transcriptome landscape of oral tongue squamous cell carcinoma along with matched potentially malignant lesions
10:20:00 Discussion
11:40:00 Poster Session A | Lunch
13:50:00 Plenary Session 2 | Oral and Head | Neck Cancer
13:55:00 Therapeutic targeting of critical pathways in head and neck cancer Jennifer Rubin Grandis
14:00:00 Radiation response-related proteins in oral squamous cell carcinomas
14:05:00 Therapy | Surgery
14:10:00 Therapy | Radiation
14:15:00 Discussion
15:40:00 Break
15:55:00 Plenary Session 3 | Cervical Cancer Douglas R. Lowy, RITA MULHERKAR
16:00:00 Descriptive epidemiology and prevention of cervical cancer
16:05:00 Transcriptional targeting in cervical cancer
16:10:00 Genomics of cervical cancer RITA MULHERKAR
16:15:00 Therapy
16:20:00 HPV16 E2 potentiates NF-κB activation induced by TNF-α through STAT3
16:25:00 ADXS11-001 immunotherapy targeting HPV-E7: preliminary safety data from a phase 2 study in Indian women with recurrent/refractory cervical cancer
16:30:00 Discussion
17:50:00 Day in Review RITA MULHERKAR, Ashok R. Venkitaraman
18:30:00 Professional Advancement Session | Networking Roundtables
18:35:00 Other topics scheduled
Thursday, December 15, 2011
08:00:00 Panel Discussion | Tobacco: Cancer, Chronic Diseases and Prevention in India
08:05:00 Introduction
08:10:00 Tobacco and cancer epidemiology in India
08:15:00 The adverse disease effects of smoking and smokeless tobacco on tuberculosis in India
08:20:00 A treetop tour of tobacco control interventions in LMIC
08:25:00 Discussion
09:30:00 Break
10:00:00 Plenary Session 4 | Breast Cancer Judy E. Garber, Annapoorni Rangarajan
10:05:00 Clinical genetics and genetic testing Judy E. Garber
10:10:00 Epigenetics of hormone dependence Myles Brown
10:15:00 Gene expression signatures in various categories of breast cancer in Indian patients
10:20:00 In vitro transformation of mammospheres generates invasive ductal adenocarcinomas harboring breast cancer cells Annapoorni Rangarajan
10:25:00 TMEPAI | A novel drug target in breast cancer therapy and prevention
10:30:00 Acquisition of oxidative stress resistance during the genesis of luminal mammary progenitors is associated with a ‘switch’ in ROS control mechanisms
10:35:00 Discussion
12:00:00 Poster Session B | Lunch
14:10:00 Plenary Session 5 | Cancer Prevention and Chemoprevention Raymond N DuBois
14:15:00 Screening for cervical cancer in low- and middle- income countries
14:20:00 Prostaglandin E2 promotes intestinal tumor growth via DNA methylation Raymond N DuBois
14:25:00 Treating tobacco dependence in the oncology setting: A prevention viewpoint
14:30:00 A Raman spectroscopy approach for classification of subsites in oral cancers: A feasibility study
14:35:00 Discussion
15:40:00 Break
16:00:00 Plenary Session 6 | Gall Bladder Cancer Pramod Garg
16:05:00 Epidemiology of gall bladder cancer in India
16:10:00 Genetics and molecular pathogenesis of gallbladder cancer
16:15:00 Chemotherapy in gall bladder cancer: Is it really needed?
16:20:00 Relationship between various biochemical, haematological, co-morbid, lifestyle, demographic parameters in gallbladder carcinoma: A single centre retrospective study of 342 patients
16:25:00 Discussion
17:30:00 Day in Review Anil K Rustgi, Raymond N DuBois, Judy E. Garber, Lalit Kumar
Friday, December 16, 2011
08:00:00 Meet-the-Expert Sessions 3-4 (concurrent)
08:10:00 Session 3 | Obesity, Inflammation and Breast Cancer Andrew J. Dannenberg
08:20:00 Session 4 | Molecular Epidemiology of Cancer: Towards Personalized Risk Assessment, Prevention, and Therapy Xifeng Wu
09:10:00 Special Lecture
09:15:00 Cancer research in India | Future direction(s)
09:30:00 Plenary Session 7 | Chronic Myelogenous Leukemia Lalit Kumar
09:35:00 Role of miRNAs in CML
09:45:00 Is CML epidemiology and natural history different in India?
09:50:00 The future of CML in India
10:00:00 Influence of hOCT1 (SLC22A1) pharmacogenetics on imatinib mesylate disposition in chronic myeloid leukemia (CML) Asian patients
10:10:00 Targeting of Fyn induction by oxidative stress is an effective strategy for overcoming kinase inhibitor resistance in chronic myeloid leukemia and treating blast crisis
10:15:00 Discussion
11:00:00 Poster Session C | Lunch
13:10:00 Plenary Session 8 | Tumor Microenvironment and Metastasis Yves A. DeClerck, Sudhir Krishna
13:20:00 EMT-MET in ovarian cancer: Metastable states or distant molecular classes? Sharmila A Bapat
13:30:00 Exploring the cross talk between Notch and Smad3 in EMT, induction of CD66+ cells and human cervical cancer progression Sudhir Krishna
13:40:00 Bone marrow mesenchymal stem cells and cancer progression in neuroblastoma Yves A. DeClerck
13:50:00 Leptin-induced breast cancer growth and metastasis: Functional interactions between leptin signaling, metastasis-associated protein 1(MTA1) and Wnt1 signaling components
14:00:00 Role of tumor microenvironment in the induction of melanoma subpopulations
14:10:00 Discussion
14:40:00 Day in Review Anil K Rustgi, Yves A. DeClerck
15:10:00 Concluding Remarks and Departure
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