3D Tissue Models
3rd Global Symposium on IGRAs
Hilton Waikoloa Village
69-425 Waikoloa Beach Drive Waikoloa, Hawaii 96738
Waikoloa, Hawaii
Students of tuberculosis have been interested in the immune response to M. tuberculosis since the modern understanding of the clinical disease. For decades the skin test response to tuberculin (TST) was the primary tool clinicians have had for study. With the development of Interferon Gamma Release Assays (IGRA) the recurrent question has been which is better, the TST or an IGRA. Hundreds of papers have been written on this matter and numerous guidelines have been issued. This conference will provide a solid framework within which to assess the rapidly moving field as well as provide a basis for making clinical decisions.

This meeting will present basic and developing information which will be of interest to academic physicians, practicing physicians such as those who practice infectious disease, pulmonary medicine, pediatrics as well as public health physicians, dermatologists, Rheumatologists, Gastroenterologists and epidemiologists.

    *   Apply up-to-date understanding of the dynamics of TB infection
    * Demonstrate and understand the interactions between immune modifiers and progression of TB infection
    * Employ up-to-date information and evidence-based expert advice to the management of clinical problems dealing with recent infections due to M. tuberculosis
    * Demonstrate the use of IGRAs in HIV infected as well as in the face of immune modifiers
    * Discuss and explain the central themes in key points of TB infection and the application of IGRA to provide a synthesis on current and emerging understanding of TB infection and risk of TB disease
    * Succinctly interpret clinical applications of IGRA results


Schedule of Presentations:

Thursday, January 12, 2012
16:00:00 Registration
17:30:00 Welcome Reception
Friday, January 13, 2012
07:30:00 Registration | Continental Breakfast
08:25:00 Welcome and Opening Remarks Antonino Catanzaro
08:30:00 The New Understanding of the Dynamics of TB Infection Clifton E. Barry
09:00:00 Discussion
09:10:00 What IGRAs Have Allowed Us to Understand About TB David Lewinsohn
09:40:00 Discussion
09:50:00 Commentary Michael D. Iseman
10:10:00 Discussion
10:20:00 Break
10:40:00 What Does the Experience with Immune Modifiers Tell Us About the Mechanism and Risk of Progression to TB Disease Robert S. Wallis
11:10:00 Discussion
11:20:00 Commentary Jerrold J. Ellner
11:40:00 Discussion
12:00:00 Luncheon
13:30:00 Do IGRAs Identify Persons Who Are Likely Not to Progress to Active TB
14:00:00 Discussion
14:10:00 How Well Do IGRAs Perform the Identification of Persons Who Are Likely to Progress to Active TB Pranab Haldar
14:40:00 Discussion
14:50:00 Break
15:10:00 Predictive Value of IGRAs for Progression to Active Tuberculosis in HIV 1 Infected Women
15:20:00 Discussion
15:25:00 Predictive Value of IGRAs for Progression to Active Tuberculosis in TB Contacts in Singapore
15:35:00 Discussion
15:40:00 Predictive Value of IGRAs and TST for Progression to Active Tuberculosis in Refugees
15:50:00 Discussion
15:55:00 Predictive Value of IGRAs for Progression to Active Tuberculosis in Children: Results of a Longitudinal Study in Germany Using IGRAs
16:10:00 Discussion
16:15:00 Commentary Ibrahim Abubakar
16:30:00 Discussion
16:40:00 Adjourn
16:45:00 Poster Session
Saturday, January 14, 2012
07:30:00 Continental Breakfast
08:30:00 Use of IGRAs In the Face of Other Co Morbidities Luca Richeldi
09:00:00 Discussion
09:10:00 Repeated Quantiferon TB Gold in Tube Tests in Routine Clinical Practice: AFive Years Experience
09:20:00 Discussion
09:25:00 Use of IGRAs in the Face of HIV Immune Modifiers
09:55:00 Discussion
10:05:00 Screening HIV Infected Patients with IGRAs for LTBI
10:15:00 Discussion
10:20:00 Break
10:40:00 Serial Testing with IGRAs in High Risk Populations
10:50:00 Discussion
10:55:00 Use of IGRAs in the Face of Immune Modifiers Stephan Gadola
11:25:00 Discussion
11:35:00 What is the Effect on the IGRA Response By Prednisolone, Tobacco or Inflammatory Bowel Disease?
11:45:00 Commentary Neil Schluger
12:05:00 Discussion
12:15:00 Luncheon
13:30:00 IGRA Testing of HCW Charles L. Daley
14:00:00 Discussion
14:10:00 Active TB in Portuguese HCW, a Descriptive Study
14:20:00 Discussion
14:25:00 IGRAs and Missed Opportunities to Prevent Active Tuberculosis in Healthcare Workers with Positive Tuberculin Skin Tests Attributed to Bacille Calmette Guerin (BCG) Vaccination
14:35:00 Discussion
14:40:00 Prevalence of LTBI in the General Public in Mazovia and HCW in Poland Using IGRAs
14:50:00 Discussion
14:55:00 Commentary
15:15:00 Discussion
15:25:00 Break
15:45:00 Interpretation of IGRA Results
16:15:00 Discussion
16:25:00 Within Subject Variability of the Quantiferon TB Gold in Tube Assay in a Large Cohort of Low Risk Subjects
16:35:00 Discussion
16:40:00 A Data Based Algorithm for the Clinical Management of Persons with Fluctuations in Serial IGRA Tests to Detect LTBI
16:50:00 Discussion
17:00:00 Commentary Matthew J. Binnicker
17:20:00 Discussion
18:30:00 Banquet and Awards
Sunday, January 15, 2012
07:30:00 Continental Breakfast
08:30:00 Dried Plasma Spots in the Diagnosis of TB Infection: IP-10 Release Assay on Filter Paper
08:40:00 Discussion
08:45:00 Pilot Study of Latent Tuberculosis Infection with an Enhanced Elispot Interferon Gamma Release Assay
08:55:00 Discussion
09:00:00 Cost Effectiveness of IGRAs Versus Chest X Ray for Tuberculosis Screening
09:10:00 Discussion
09:15:00 Cost Effectiveness and Operating Characteristics of Using IGRAs in US Healthcare Workers
09:25:00 Discussion
09:30:00 Screening of HCW and Immigrants with IGRA and TST in Mexico
09:40:00 Discussion
09:45:00 Commentary
10:05:00 Discussion
10:15:00 Break
10:30:00 The Use of IGRAs in Pediatrics
11:00:00 Discussion
11:30:00 Commentary Jeffrey R. Starke
12:00:00 Discussion
12:10:00 Luncheon
13:30:00 Adding Treatment of LTBI to Global TB Control Laith J. Abu-Raddad
14:00:00 Eliminating TB by 2050 Mario Raviglione
14:30:00 Discussion
14:40:00 Global Applications
15:10:00 Break
15:30:00 Commentary
15:50:00 A New Treatment of LTBI
16:20:00 Role of IGRAs in the Eradication of TB
16:50:00 Closing Comments
17:00:00 Adjourn
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