Monogenic Disorders of Insulin Secretion:Congenital Hyperinsulinism and Neonatal Diabetes
Translational Research Building
3614 Civic Center Blvd
Philadelphia, PA
This two-day international symposium
will be an update on recent exciting
advances in research related to congenital
hyperinsulinism and neonatal diabetes.
The symposium is intended to enhance the
clinical management skills and practices of
endocrinologists, neonatologists, surgeons,
pathologists, radiologists, geneticists and
nurses, as well as basic scientists interested
in pancreatic islet biology and regulation of
insulin secretion. The symposium faculty,
chosen from nine institutions in the United
States, France, Great Britain, Norway,
Switzerland and Finland, will present 22
plenary lectures on all aspects of these
Participants may register via mail or facsimile
by completing the Registration Form
attached to the brochure and indicating their
form of payment. To register online go to
Provide an overview of the clinical
manifestations, genetics and natural
history of congenital hyperinsulinism.
• Review current knowledge of the normal
regulation of insulin secretion and the
pathophysiology of disorders causing
hyperinsulinism and neonatal diabetes
• Discuss recent advances and current
controversies in the surgical and medical
management of diffuse and focal

The program includes two sessions at
which attendees may present posters and
short oral communications of their own
clinical or laboratory research. Abstracts
must be submitted electronically using
the registration form on the Congenital
Hyperinsulinism Symposium website
( The deadline for
abstract submission is Thursday, Dec. 15,
2011. Authors will be notified of abstracts
accepted for poster or oral presentations
by Wednesday, Feb. 1, 2012. A limited
number of travel grants will be available to
young investigators wishing to apply. Young
investigators must apply at the time they
register for the symposium and submit their

Schedule of Presentations:

Thursday, March 15, 2012
07:25:00 Session 1 | Common Forms of Genetic Hyperinsulinism – KATP Channels and Hyperinsulinism
07:30:00 Registration and Continental Breakfast
08:15:00 Welcome, Introductions and Symposium Overview Charles A. Stanley
08:30:00 KATP-channel Hyperinsulinism Variations Charles A. Stanley
09:00:00 Genotype-phenotype of Expressed KATP-HI Mutations Show Ling Shyng
09:30:00 Glucokinase Hyperinsulinism Charles A. Stanley
10:00:00 Break and Exhibits
10:30:00 CONCURRENT SESSIONS | Common Forms of Genetic Hyperinsulinism – GDH and Hyperinsulinism
10:30:00 Amino Acid Stimulated Insulin Secretion in Hyperinsulinism Mouse Models Changhong Li
11:00:00 Glutamate Dehydrogenase Hyperinsulinism Andrea Kelly
11:30:00 Lessons Learned from Tissue-specific GDH Knockout Mice Pierre Maechler
12:00:00 Luncheon, Exhibits and Scientific Posters
13:30:00 CONCURRENT SESSIONS | Management of Genetic Hyperinsulinism – Part 1
13:35:00 Focal Congenital Hyperinsulinism Pascale de Lonlay
14:00:00 [18F]-DOPA PET Imaging of Focal Hyperinsulinism: “GPS” for the Surgeon Lisa J. States
14:30:00 Surgery for Hyperinsulinism N. Scott Adzick
15:00:00 Break, Exhibits and Scientific Posters
15:10:00 Session 4 | Management of Genetic Hyperinsulinism – Part 2
15:15:00 Panel Discussion
16:00:00 Free Communications
17:00:00 Adjourn
18:00:00 Symposium Reception and Dinner (optional)
Friday, March 16, 2012
07:25:00 CONCURRENT SESSIONS | New Forms of Genetic Hyperinsulinism – Part 1
07:30:00 Registration and Continental Breakfast
08:00:00 Molecular Diagnosis of Congenital Hyperinsulinism Arupa Ganguly
08:30:00 HNF4a – Hyperinsulinism Khalid Hussain
08:50:00 SCHAD – Hyperinsulinism Anders Molven
09:10:00 MCT1 – Hyperinsulinism Timo Otonkoski
09:30:00 UCP2 and Hyperinsulinism
09:50:00 Break, Exhibits and Scientific Posters
10:15:00 Session 6 | New Forms of Genetic Hyperinsulinism – Part 2
10:20:00 Perinatal Stress Hyperinsulinism Charles A. Stanley
10:40:00 GLP-1 Receptor: A Target for Treating Hyperinsulinism Diva D. De León-Crutchlow
11:00:00 Brief Communications and Oral Abstracts
12:00:00 Luncheon, Exhibits and Scientific Posters
12:55:00 Session 7 | Monogenic Diabetes – Part 1
13:00:00 Keynote Address: The Genetics of Diabetes Mellitus Graeme I. Bell
13:35:00 Transcriptional Regulation of Pancreas Development and Function Doris A. Stoffers
14:10:00 KATP Neonatal Diabetes Atma W. Greeley
14:40:00 Mutations in the Insulin Gene and Diabetes
15:15:00 Break
15:25:00 Session 8 | Monogenic Diabetes – Part 2
15:30:00 Beyond the ß-cell in Diabetes: CEL and Other Forms of Diabetes Involving the Exocrine Pancreas Pål R. Njølstad
16:00:00 Case Studies in the Many Causes of Neonatal Diabetes Atma W. Greeley
16:30:00 Hyperinsulinism and Monogenic Diabetes: Free Communications
17:00:00 Adjourn
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