4th World Epigenetics Summit
Doubletree by Hilton Hotel London – West End
92 Southampton Row
London, GB
4th World Epigenetics Summit 
Doubletree by Hilton Hotel London – West End

Schedule of Presentations:

Tuesday, December 4, 2012
07:30:00 Registration, Coffee and Networking
08:20:00 Chair’s Opening Remarks Chas Bountra
08:30:00 What is the Broad Therapeutic Potential for Epigenetic Drugs and How Can We Realise This Quickly? Chas Bountra
09:00:00 Epigenetic Protein Families: A New Frontier in Small Molecule Drug Discoverys Paul Fish
09:30:00 Translating Chromatin Biology into Clinically Effective Drugs
10:00:00 Morning Refreshments and Speed Networking Udo Oppermann
12:00:00 Selective Inhibition of BET Bromodomains as a New Epigenetic Frontier in Oncology Tony Kouzarides
12:30:00 Prospects of Histone Methyltransferase & Demethylase Inhibitors in Personalised Cancer Therapy Stefan Kubicek
13:00:00 Lunch
14:00:00 Uncovering Differentiation in Epigenetic Therapy by Targeting LSD-1 Anuradha Ganesan
14:30:00 Strong and Specific LSD1 Inhibitors and Their Application for the Treatment of Cancer Tamara Maes
14:30:00 Harnessing HMT Inhibition Uncovers a New Avenue in Epigenetic Cancer Therapy
15:00:00 Afternoon Refreshment Break
15:30:00 Developing the DNMT Paradigm by Fragment Based Drug Design Tom Heightman
16:00:00 Design & Development of Isoform Selective HDAC Inhibitors for the Treatment of Inflammatory Disease & Cancer Stephen Shuttleworth
16:30:00 Chair’s closing remarks
16:40:00 Poster Session and Drinks Reception
Wednesday, December 5, 2012
Thursday, December 6, 2012
08:50:00 Chair’s Opening Remarks Chas Bountra
09:00:00 Relating Epigenetic Changes to Disease Indications: Prospects for Diagnosis, Drug Targets & Personalised Medicine Tim Spector
09:30:00 Mapping the DNA Methylome in Type 2 Diabetes to Stratify Patient Populations
10:00:00 Epigenetics - Impact for Translational and Drug Safety Sciences Remi Terranova
10:30:00 Morning Refreshment Break
11:00:00 Pharmacoepigenomics & DNA Methylation Biomarkers in Ovarian Cancer Treatment Bob Brown
11:30:00 Using Epigenetic Targets to Approach Autoimmune & Inflammatory Disease Indications Rabinder Prinjha
12:00:00 The Macrophage Epigenome & the Control of Inflammatory Gene Expression Gioacchino Natoli
12:30:00 Lunch
13:30:00 Epigenetic Modifications: Novel Therapeutic Strategies for Systemic Sclerosis & Rheumatoid Arthritis Steffen Gay
14:00:00 Selective Induction of Gene Expression by Targeting Long Non-Coding RNA: Prospects for Whole Spectrum Disease Therapy Art Krieg
14:30:00 Panel Session: Replenishing the Pipeline – Where Will Innovation & Differentiation Come From in Epigenetic Drug Development Trevor Perrior , Peter Birk
15:00:00 Afternoon Refreshment Break
15:30:00 Optimizing the Performance of HDACi Therapy by Use of a Companion Biomarker Platform Nicholas B La Thangue
16:00:00 Resminostat: Translating Epigenetic Regulation to Clinical Oncology Stefan Henning
16:30:00 Chairman’s Closing Remarks
3D Tissue Models
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