Schedule of Presentations:

Sunday, January 20, 2013
19:00:00 Welcoming Remarks
19:10:00 Keynote Address | Metastasis and diversity in breast cancer
20:00:00 Opening Reception
Monday, January 21, 2013
07:00:00 Continental Breakfast
08:00:00 Session 1: The Soil Zena Werb
08:15:00 Microenvironmental control of bone metastasis Sylvain Provot
08:30:00 The role of the microenvironment protein cathelicidin LL-37 in pancreatic ductal adenocarcinoma Christopher Heeschen
08:45:00 Normalizing tumor cell metabolism in breast cancer metastasis: A novel therapeutic approach Brunhilde Felding-Habermann
09:00:00 Identification of luminal breast cancers that establish a tumor supportive macroenvironment defined by proangiogenic platelets and bone marrow derived cells Timothy Marsh
09:30:00 The extracellular matrix is fertile soil Richard Hynes
10:00:00 Break
10:30:00 Session 2: Determinants of Tumor Metastasis Y Kang
10:45:00 Development of a therapeutic peptide for the treatment of metastatic cancer Christine A. Iacobuzio-Donahue
11:00:00 The cholesterol metabolite 27-hydroxycholesterol increases breast cancer tumor growth and metastasis Erik Nelson
11:15:00 Epithelial-mesenchymal plasticity in breast cancer metastasis Y Kang
11:30:00 Targeted functional genomics screen for novel metastasis modulators in breast cancer Angela Riedel
11:45:00 Macrophages as a therapeutic target in invasive gliomas Johanna A Joyce
12:45:00 Poster Session A / Lunch
15:00:00 Session 3: Imaging Metastasis Matthew Krummel
15:15:00 Real-time microscopy of brain metastasis formation: From blood vessels to cancer stem cells Frank Winkler
15:30:00 Intravital multiphoton imaging reveals multicellular streaming as a crucial component of in vivo cell migration in human breast tumors Antonia Patsialou
15:45:00 Imaging metastasis in the lung Matthew Krummel
16:00:00 Intravital imaging of metastatic liver colonization Laila Ritsma
16:30:00 Issues in the development of molecular imaging agents for cancer imaging: An observation from the MICAD editors
17:15:00 Poster Session B / Reception
19:15:00 Dinner on Own / Evening Off
Tuesday, January 22, 2013
07:00:00 Continental Breakfast
08:00:00 Session 4: Metastasis Signaling Pathways Joan Massagué
08:15:00 Niches and pathways of latent and overt metastasis Joan Massagué
08:30:00 A distinct translational regulon driven by mTOR signalling steers cancer metastasis
08:45:00 The MSP/Ron pathway as a driver of breast cancer metastasis
09:00:00 miR-15b and its novel target metastasis suppressor 1 (MTSS1) are part of a global network of coding and noncoding EGF-stimulated genes Merav Kedmi
09:30:00 HIFs, hypoxia, and tumor progression M. Celeste Simon
10:00:00 Break
10:30:00 Session 5: Angiogenesis and Inflammation in Metastasis Melody A Swartz
10:45:00 Lymphatic vessels in the tumor microenvironment contribute to protumor immune modulation Melody A Swartz
11:00:00 Regulation of metastasis via tumor-stromal interactions Randolph S Watnick
11:00:00 Targeting the HIF-1α/p300 complex with epidithiodiketopiperazines for antiangiogenic therapy Kelie Reece
11:15:00 High angiogenic capacity of inflammatory neutrophils and polarized M2 macrophages is determined by production of MMP-9 unencumbered by its natural inhibitor TIMP-1 Ewa Zajac
11:30:00 Circulating tumor cells: Biology and relevance for cancer therapy Klaus Pantel
12:30:00 Poster Session C / Lunch
14:30:00 Forum: Cancer Stem Cells and Metastasis
14:45:00 Understanding the dynamics of cancer: From molecular pathways to in vivo imaging Tannishtha Reya
15:00:00 Deregulation of stem cell self-renewal pathways in cancer Michael F. Clarke,
15:30:00 Modeling the breast cancer bone metastatic niche Gabriela Dontu
16:00:00 Session 6: Metastatic Signatures Samir M. Hanash
16:15:00 GEM models in translational research Lynda Chin
16:30:00 Collective invasion in breast cancer is led by cancer cells distinguished molecularly by basal epithelial markers Kevin Cheung
16:45:00 Cancer stem cells and the mechanisms of metastatic dissemination Robert A Weinberg
17:00:00 Identifying different functional mechanisms of invasion from mesenchymal and proneural subtypes of glioblastoma Sungwon Jung
17:30:00 The microenvironment as a source of markers for the early detection of cancer Samir M. Hanash
18:00:00 Dinner on Own / Evening Off
Wednesday, January 23, 2013
07:00:00 Continental Breakfast
08:00:00 Session 7: Metastatic Dormancy Douglas Fearon
08:15:00 Immune cells promote metastasis and control dormancy Jean-Pierre Abastado
08:30:00 microRNAs: Master regulators of human tumor dormancy Nava Almog
08:45:00 Pathways in tumor dormancy and recurrence Lewis A. Chodosh
09:00:00 ErbB2-induced epithelium to mesenchyme transition (EMT) is blocked by p38α/β; signaling to restrict early dissemination in breast cancer Kathryn Harper
09:30:00 The FAP+ stromal cell and escape from immune surveillance Douglas Fearon
10:00:00 Break
10:15:00 Session 8: Treatment of Metastatic Cancer Bruce R. Zetter
10:30:00 Targeting stress-induced chaperones CLU and Hsp27 to inhibit EMT and metastases Martin E. Gleave
10:45:00 Antitumor effect of metformin in breast cancer is associated with AMPK and FOXO3a activation Elaine Fonseca
11:00:00 Models of postsurgical early and late stage metastasis for improving preclinical adjuvant and metastatic therapy investigations Robert S Kerbel
11:15:00 Omic and imaging approaches to understanding breast cancer progression Joe W Gray
11:30:00 Short talk from proffered abstract
12:00:00 Closing Remarks and Departure
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