Understanding Dendritic Cell Biology to Advance Disease Therapies (C2)

Schedule of Presentations:

Sunday, March 3, 2013
16:00:00 Arrival and Registration | Longs Peak Foyer
Monday, March 4, 2013
07:00:00 Breakfast
08:00:00 Welcome and Keynote Address
08:05:00 Ralph Steinman and the Dendritic Cell Discovery Michel C. Nussenzweig
09:00:00 Development of Tissue-Resident and Inflammatory DC
09:10:00 The DC Lineage Miriam Merad
09:20:00 Regulation of Plasmacytoid Dendritic Cell Development and Function Boris Reizis
09:30:00 Fine-Grained Analysis of the Macrophages and Dendritic Cells Present in the Mouse Skin Bernard Malissen
09:40:00 Coffee Break
09:50:00 Transcriptional Control of DC Development
10:00:00 Revisiting the Ontogeny of the Mononuclear Phagocyte System: Embryonic and Adult Hematopoietic Contributions Florent Ginhoux
10:10:00 Short Talk: The Chemokine Receptor XCR1 is a Lineage Marker for Cross-Presenting DCs Richard A. Kroczek
12:15:00 Poster Setup
13:00:00 Poster Viewing
14:00:00 On Own for Lunch and Recreation
14:30:00 Workshop 1: Transcriptional Control of DC Development and Function Bernard Malissen, Nir Hacohen
14:40:00 A Modular Transcriptional Framework Characterizes Human Dendritic Cell Responses to Pathogens and Vaccines
14:50:00 Dendritic Cells in Human Primary Immunodeficiencies: Insights into DC biology Venetia Bigley
15:00:00 Recombination Activating Gene-2 Regulates CpG-Mediated Interferon-alpha Production in Mouse Bone Marrow-Derived Plasmacytoid Dendritic Cells Xin M. Luo
15:10:00 Identification of the Receptor Tyrosine Kinase Axl as a Downstream Effector of TGF-beta1 during Langerhans Cell Differentiation and Epidermal Homeostasis Herbert Strobl
15:20:00 Conventional Dendritic Cell Precursors Give Rise to Four Distinct Subsets of Dendritic Cells in the Steady State Intestine
15:30:00 What does Gata1 do to Dendritic Cells? Laura Gutierrez
15:40:00 Gene Profiling of Dendritic Cell Subsets after in vivo Administration of TLR3 Agonist in Healthy Human Volunteers
15:50:00 IL-2 Inhibits Dendritic Cell Development by Acting on Precursors and Altering DC-Associated Transcription Factors Alan Guerrero
16:30:00 Coffee Available
17:00:00 Transcriptional Control of DC Development and Function
17:10:00 Functional Specialization of Human DC Subsets Hideki Ueno
17:20:00 Genes and Networks Underlying Dendritic Cell Activation Nir Hacohen
17:30:00 Systems Vaccinology: Enabling Rational Vaccine Design with Systems Biology Bali Pulendran
17:40:00 Short Talk: Single Hematopoietic Progenitor Tracing Reveals Dendritic Cells are a Distinct Lineage Shalin H. Naik
19:00:00 Social Hour w/ Lite Bites
19:30:00 Poster Session 1
Tuesday, March 5, 2013
07:00:00 Breakfast
08:00:00 Cell Biology and Antigen Processing
08:10:00 ER Stress and DC Function Bart N. Lambrecht
08:20:00 Ubiquitination and DC Functions Averil Ma
08:30:00 MicroRNA Control of DC Development Brian D. Brown
08:40:00 Short Talk: Developmental Regulation of Dendritic Cell Migration Pablo Vargas
08:50:00 Short Talk: Leishmania Inhibits Crosspresentation through the Cleavage of VAMP8
09:00:00 Short Talk: HIV-1 Infection-Induced Apoptotic Microparticles Inhibit Human Dendritic Cells via CD44 Davor Frleta
09:20:00 Coffee Break
11:00:00 Poster Setup
13:00:00 Poster Viewing
14:00:00 On Own for Lunch and Recreation
14:30:00 Workshop 2: Regulation of DC Function Caetano Reis e Sousa, Peter Lee
14:40:00 The Human Dendritic Cell Phagosome Proteome: Novel Players and Implications for the Regulation of Receptor Mediation Phagocytosis Sonja I. Buschow
14:50:00 Mice with Conditional Deletion of NF-kappaB–Inducing Kinase (NIK) in Dendritic Cells Show Defective CD40-Dependent Antigen Cross-Priming of CD8+ T Cells C Austin
15:00:00 Ubiquitin-Mediated MHCII Turnover Promotes Dendritic Cell Selection of Natural Regulatory T Cells Jeoung-Sook Shin
15:10:00 Intercellular Transfer of Regulatory T Cell Specific MicroRNA to Dendritic Cells Leads to Modulation of Dendritic Cell Function Lesley Ann Smyth
15:20:00 Dendritic Cell Homeostasis is Maintained by Non-Hematopoietic and T Cell-Produced Flt3-Ligand in Steady-State and during Antigen-Specific Immune Responses Yasuyuki Saito
15:30:00 Critical Role of Linear Ubiquitin Regulator SHARPIN in NF-kappaB Signaling and Induction of TH1 Cells by Dendritic Cells Zhen Wang
15:40:00 The NF-kB Regulator Bcl-3 Plays a Critical Role in the Initiation of Adaptive Immune Responses Ilaria Tassi
15:50:00 Dynamic Imaging Reveals Promiscuous Cross-Presentation of Blood-Borne Antigens to Naïve CD8+ T Cells in the Bone Marrow Guy Shakhar
16:30:00 Coffee Available
17:00:00 Molecular and Functional Aspects of DC Migration Gwendalyn J. Randolph
17:10:00 Lymph Node Homing of DCs, pDCs, and Activated T Cells via Afferent Lymphatics Reinhold Förster
17:20:00 Cytoskeletal Dynamics of Dendritic Cells Michael Sixt
17:30:00 Short Talk: NOD-like Receptor NLRP10 Regulates Migration of CD11b-Positive Dendritic Cells Stephanie C. Eisenbarth
19:00:00 Social Hour w/ Lite Bites
19:30:00 Poster Session 2
Wednesday, March 6, 2013
07:00:00 Breakfast
08:00:00 DC Sensing of the Environment
08:10:00 Inflammasome Activation in Macrophages and DC Eicke Latz
08:20:00 DC HIV Interaction Monsef Benkirane
08:30:00 Defining Dendritic Cells by Ontogeny Caetano Reis e Sousa
08:40:00 Gut Microbiota Influences T Cell-Dependent Anticancer Immunity during Chemotherapy Laurence Zitvogel
08:50:00 Short Talk: Commensal Microbiota Modulates the Innate Response to Cancer Immunotherapy and Chemotherapy Romina Silvana Goldszmid
09:00:00 Short Talk: HIV Capsid Dissociates Cytosolic Sensing and Productive Infection in Dendritic Cells Nicolas Manel
09:20:00 Coffee Break
11:15:00 Poster Setup
13:00:00 Poster Viewing
14:00:00 On Own for Lunch and Recreation
16:30:00 Coffee Available
17:00:00 Role of PDC in Immunity and Disease
17:10:00 Biochemical Characterization of Nucleic Acid Sensors in Dendritic Cells Yong-Jun Liu
17:20:00 PDC in Host Defense Marco Colonna
17:30:00 New DC Progenitors with Prominent pDC Differentiation Potential Toshiaki Ohteki
17:40:00 Short Talk: LC3-Associated Phagocytosis Mediates IFN-alpha Secretion in Response to DNA-Immune Complexes
19:00:00 Social Hour w/ Lite Bites
19:30:00 Poster Session 3
Thursday, March 7, 2013
07:00:00 Breakfast
08:00:00 Role of DC in Pathogenesis
08:10:00 DC Control of T Helper Cell Development Federica Sallusto
08:20:00 Dendritic Cells, Receptors and Initiation of Immunity William R. Heath
08:30:00 Critical Dendritic Cell / Macrophage Crosstalk in the Intestinal Lamina Propria Steffen Jung
08:35:00 Role of Dendritic Cells in the Pathogenesis of Asthma Hamida Hammad
08:40:00 Short Talk: Interferon Regulatory Factor 4 (IRF4) in Dendritic Cells (DCs) Promotes Th2 Responses and Regulates IL-10 and IL-33 Production Jesse W. Williams
08:50:00 Short Talk: Influence of Apoptotic Cell Death on Tumor Immunity Matthew L. Albert
09:00:00 Coffee Break
14:00:00 On Own for Lunch and Recreation
14:30:00 Workshop 3: Role of DC in Pathogenesis Zoltan Fehervari, Anna Karolina Palucka
14:40:00 Enhanced RNA-Sensing in Dendritic Cells (DCs) is Required for the Development of Severe Disease in SLE-Prone Mice Teja Celhar
14:50:00 Complement Proteins Produced by Dendritic Cells Control Effector T Cell Differentiation and Regulatory T Cell Function
15:00:00 TSLP-Dependent and Independent Induction of Th2 Responses via Dermal Dendritic Cells Sotaro Ochiai
15:10:00 In vivo Targeting of a Self-Antigen Reveals a Specialized Role for Migratory Langerin+ Dendritic Cells in the Generation of Foxp3+ Regulatory T Cells Juliana Idoyaga
15:20:00 Comparing pre-DC and Monocyte-Derived Cell Heterogeneity and Function in Non-Lymphoid Organs Heidi A. Schreiber
15:30:00 Dendritic Cells Control CNS Autoimmunity by Induction of Tregs through PD-L/PD-1 Interaction Nir Yogev
15:40:00 Plasmacytoid Dendritic Cells Deficient in IFN-alpha Production Promote the Amplification of FOXP3+ Regulatory T Cells though ICOS/ICOS-L Interaction in Breast Cancer Nathalie Bendriss-Vermare
15:50:00 Critical Role of Plasmacytoid Dendritic Cells in Immunoregulation Initiated by a Commensal Microbial Polysaccharide Suryasarathi Dasgupta
16:30:00 Coffee Available
17:00:00 Harnessing DC Biology to Advance Disease Therapies Ira Mellman
17:10:00 DC in Celiac Disease Bana Jabri
17:20:00 TLR Recognition of Self Nucleic Acids in Acute and Chronic Inflammation
17:30:00 Reprogramming the Immune Environment in Cancer via Dendritic Cells Anna Karolina Palucka
18:30:00 Concluding Remarks
18:40:00 Translating DC Biology into Medicine Ira Mellman
19:15:00 Social Hour w/ Lite Bites
20:00:00 Entertainment
Friday, March 8, 2013
09:00:00 Departure
3D Tissue Models
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