Cardiac Biology - From Development to Regenerative Medicine

Heidelberg, Germany
Regenerative medicine is a prime example of the interdisciplinary trend in contemporary biomedical research, incorporating developmental and stem cell biology, biomaterials and tissue engineering, gene and cell therapeutic approaches. The science underpinning recent advances in tissue repair has already provided significant clinical outcomes in many organ systems, yet the challenges facing regeneration of the cardiovascular system are particularly complex. The mature mammalian heart is particularly refractory to recovery after insult, mysteriously losing the robust cardiac regenerative capacity of the embryo, which is retained by other species into adulthood.

Schedule of Presentations:

Friday, June 7, 2013
11:15:00 New Registration and Lunch
13:15:00 Opening remarks Matthias W. Hentze
13:30:00 A lineage tree for myocardial cells that form the heart Or A regulatory switch that operates in progenitor cells in the second heart field and myocardial cells in the heart Margaret Buckingham
13:30:00 Heart development
14:00:00 TBA Ken Poss
14:30:00 Hey bHLH target genes in cardiovascular development
14:45:00 Regulation of atrioventricular epithelial-to-mesenchymal transition by microRNAs
15:00:00 Coffee Break
15:30:00 TBA Cecilia Lo
16:00:00 YAP1 in heart development, function, and regeneration William T Pu
16:30:00 Unilateral dampening of Bmp activity by Nodal generates cardiac left-right asymmetry
17:00:00 Coffee break
17:30:00 The Molecules and Mechanisms of Heart Development, Disease and Regeneration Eric N Olson
18:30:00 Dinner in the EMBL Canteen
20:00:00 After dinner drinks in the ATC Rooftop Lounge
Saturday, June 8, 2013
08:30:00 Morning coffee
09:00:00 Identifying evolutionary conserved transcriptional networks for electrical patterning of the heart Vincent Christoffels
09:30:00 TBA Didier Stainier
10:00:00 The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse
10:15:00 A genetic polymorphism in ALDH2 regulates cell viability and increases ischemic damage to iPSC-derived cardiomyocytes
10:30:00 Coffee Break
11:00:00 Crosstalk between chromatin remodeling, transcription factors and histone modifications Silke Sperling
11:30:00 Epigenetic control of cardiac function Stefanie Dimmeler
12:00:00 The calcineurin splicing variant improves cardiac remodelling post-infarction and reduces cardiac hypertrophy after transaortic banding
12:15:00 Molecular circuits controlled by Sirt1 during heart development
12:30:00 Poster and Lunch
14:25:00 Session 3: Progenitors in the Developing Heart
14:30:00 Cardiac transcription factor networks - targeting the kernel Richard Harvey
15:00:00 Cardiomyocyte cell cycling and myocardial growth and regeneration in mice and humans Bernhard Kuhn
15:30:00 Heartbeat driven pericardiac fluid forces direct epicardium morphogenesis
15:45:00 Endodermal S1P-Yap signaling regulates cardiogenesis by controlling cardiac precursor cell migration Naoki Mochizuki
16:00:00 Coffee Break
16:30:00 Epicardium-derived DIY heart repair Paul Riley
17:00:00 Regulation of cardiac progenitor cell expansion
17:30:00 TBA
18:30:00 Dinner in the EMBL Canteen
20:00:00 After dinner drinks in the ATC Rooftop Lounge
Sunday, June 9, 2013
08:30:00 Morning coffee
09:00:00 Design and Functional Analysis of High-Level Tissue-Specific Regulatory Cassettes for Gene- & Cell-Mediated Cardiac Therapy
09:30:00 TBA Ken Chien
10:00:00 Smad1 integrates BMP2 and Wnt3a signals during cardiac progenitor cell migration
10:15:00 Alterations in Ciliogenesis and Centrosome Integrity During Cardiomyocyte Terminal Differentiation
10:30:00 Coffee Break
11:00:00 iPSCs for cardiac disease modeling and drug screening
11:30:00 Induced Pluripotent Stem Cells: Implications for Basic and Translational Cardiovascular Research Lior Gepstein
12:00:00 Unmasking Phenotypic Micro-heterogeneities in Adult Cardiac Progenitor Cells: Clonal Analysis, Fate Mapping, and Single Cell QRT-PCR Michael D Schneider
12:15:00 Cell-autonomous Fgf10 signaling regulates cardiomyocyte proliferation in the right ventricle of the fetal mouse heart
12:30:00 Poster and Lunch
14:30:00 Session 5: Regenerative Biology
14:30:00 Molecular circuits controlling myocardial remodeling and regeneration Thomas Braun
15:00:00 Maturational growth of the preadolescent heart: implications for the timing of cardiomyocyte terminal differentiation Ahsan Husain
15:30:00 Hypoxia induces myocardial regeneration in zebrafish
15:45:00 Cardiomyocyte Renewal in Growing and Adult Human Hearts
16:00:00 Coffee break
16:30:00 TBA Nadia Rosenthal
17:00:00 Stem Cell-based modulation of Heart Function Bernd Fleischmann
17:30:00 Regenerative Nanomedicine for the Cardiovascular System Samuel I. Stupp
18:30:00 Conference Dinner and party
Monday, June 10, 2013
08:30:00 Morning Coffee
09:00:00 Session 6: Translation
09:00:00 Cell therapy of post-infarction heart failure: determinants of clinical efficacy Andreas Zeiher
09:30:00 TBA Silviu Itescu
10:00:00 Small molecule screen identifies carbacyclin as an inducer of mammalian cardiomyocyte proliferation
10:15:00 Heart regeneration and tumorigenicity: oncogenic ErbB2 as a driving force
10:30:00 Coffee Break
11:00:00 Cardiogenesis with Pluripotent Human Stem Cells Chuck Murry
11:30:00 Functional and anatomically effective myocardial regeneration through the stimulation of the endogenous cardiac stem cells
12:30:00 Closing remarks
13:00:00 Lunch and poster session
15:15:00 Departure
3D Tissue Models
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