3D Tissue Models
8th Brain Research Conference: RNA metabolism in Neurological Disease
Sheraton San Diego Hotel & Marina
1380 Harbor Island Drive
San Diego, CA 92101, USA
8th Brain Research Conference: RNA metabolism in Neurological Disease 
Sheraton San Diego Hotel & Marina
1380 Harbor Island Drive
San Diego, CA 92101

Schedule of Presentations:

Thursday, November 7, 2013
06:00:00 New Presentation
06:00:00 New Presentation
06:00:00 New Presentation
07:30:00 Registration
08:15:00 [IS1.1] Pathology of RNA Binding Proteins in ALS and Related Disorders: Lessons from Genetics Robert H. Brown Jr
08:45:00 [IS1.2] Expanded G4C2 repeats linked to C9ORF72 ALS and FTD form length-dependent RNA foci, sequester RNA binding proteins and are neurotoxic
09:15:00 [IS1.3] Association between repeat sizes and clinical and pathological characteristics in C9ORF72 repeat expansion carriers Rosa Rademakers
09:45:00 [ST1.1] RAN translation at CGG Repeats: Mechanisms and roles in FXTAS pathogenesis
10:00:00 Refreshment break
10:30:00 [IS2.1] RNA-binding proteins and RNA-mediated disease mechanisms in microsatellite expansion disorders Maurice S. Swanson
11:00:00 [IS2.2] RAN translation in neurologic disease: Lessons from SCA8, DM and ALS/FTD Laura Ranum
11:30:00 [IS2.3] Elucidating the mechanisms of RNA-mediated toxicity and haploinsufficency in C9orf72 repeat carriers Leonard Petrucelli
12:00:00 [ST2.1 ] Modelling C9orf72 pathomechanisms in zebrafish
12:15:00 Lunch
13:15:00 Poster session 1 | Nautilus
14:45:00 [IS3.1] Predicting the effects of mutations in human prion-like proteins Eric Ross
15:15:00 [IS3.2] Test tube reconstitution of neuronal granules Steven McKnight
16:15:00 [IS4.1] Mechanism and therapy for errors in RNA binding proteins in ALS and FTD Don W Cleveland
16:45:00 [IS4.2] TDP-43 Proteinopathies
17:15:00 [ST4.1] Contributions of RNA binding Proteins to Alzheimer’s disease
17:30:00 [ST4.2] The Parkinson’s disease-associated PINK1 kinase regulates the recruitment and translation of nuclear-encoded mitochondrial mRNAs
17:45:00 Welcome Reception | Nautilus – Lower Level
Friday, November 8, 2013
08:15:00 [IS5.1] Mechanistic and pathway insight into the interaction between TDP-43 and Ataxin-2 in ALS/FTD Nancy M. Bonini
08:45:00 [IS5.2] A novel role for profilin 1 in stress granules Aaron Gitler
09:15:00 [IS5.3] ESCRTs, MicroRNAs, and Frontotemporal Dementia Fen-Biao Gao
09:45:00 [ST5.1] Causes and consequences for dysregulated microRNAs in ALS Eran Hornstein
10:00:00 Refreshment break | Nautilus – Lower Level
10:30:00 [IS6.1] Altered Ribostasis: The role of perturbed RNA metabolism in neurodegenerative and myodegenerative disease J. Paul Taylor
11:00:00 [IS6.2] The eukaryotic mRNA cycle: Movement of yeast mRNAs between polysomes, stress granules, and P-bodies and its role in the control of translation and degradation Roy Parker
11:30:00 [ST6.1] RNA-centric view on the angiogenin-mediated neuroprotection: Implications for ALS Pavel A Ivanov
11:45:00 [ST6.2] A potential role for mislocalization and/or mis-function of the FUS-interacting partners, RNAP II, U1 snRNP, and the SMN complex, in ALS pathogenesis
12:00:00 Lunch | Nautilus – Lower Level
12:45:00 Poster session 2 | Nautilus – Lower Level
14:15:00 [IS7.1] C9orf72 ALS/FTD: RNA Toxicity, development of antisense therapy and biomarkers thru human induced pluripotent cells Jeffrey D. Rothstein
14:45:00 [IS7.2] RNA G-Quadruplex structures of the C9orf72 repeat, r(GGGGCC)nFormation and disruption of RNA-binding protein complexes Christopher Pearson
15:15:00 Refreshment break | Nautilus – Lower Level
15:45:00 [ST8.1] SMN is required for RNA splicing in sensory-motor circuits Brian D. McCabe
16:00:00 [IS8.1] Antisense splicing modulation for therapy and modeling of CNS disease Adrian Krainer
16:30:00 [IS8.2] Rational design of small molecules targeting RNAs associated with neurological disorders Matthew Disney
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