3D Tissue Models
Gordon Research Seminar: Plasminogen Activation & Extracellular Proteolysis
Four Points Sheraton / Holiday Inn Express

Ventura, CA
The Plasminogen Activation & Extracellular Proteolysis Gordon Research Seminar will be held in conjunction with the Plasminogen Activation & Extracellular Proteolysis Gordon Research Conference. Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Please refer to the Plasminogen Activation & Extracellular Proteolysis GRC web page for more information. 

Schedule of Presentations:

Saturday, February 8, 2014
14:00:00 Arrival and Check-in
15:30:00 Introductory Comments by GRC Site Staff
15:40:00 Welcome by the GRS Conference Chairs
15:50:00 Molecular Mechanisms of Extracellular Proteolysis James Whisstock
15:55:00 Role of the serpin protease nexin-1 in tissue remodeling occurring during pulmonary fibrosis Deborah Francois
16:05:00 Discussion
16:10:00 Generation and characterization of homozygous plasminogen-Tochigi mutant mice bearing reduced fibrinolytic activity Yuko Tashima
16:25:00 Discussion
16:30:00 Poster Session I (odd-numbered posters)
18:00:00 Dinner
19:30:00 Molecular Mechanisms of Extracellular Proteolysis (continued) James Whisstock
19:35:00 Urokinase provides a negative feedback between plasminogen activation and cell adhesion through uPAR-dependent cleavage of vitronectin
19:45:00 Discussion
19:50:00 Genetic Deletion of LDL Receptor Family Members Supports Thrombus Resolution in a Mouse Model of DVT
20:05:00 Discussion
20:10:00 Developing A Model For PAI-1: VN Interactions Letitia Olson
20:25:00 Discussion
20:30:00 Pinpointing the Molecular Basis for Metal Effects on PAI-1 Joel Bucci
20:45:00 Discussion
20:50:00 Keynote Session Sharon Stack
21:20:00 Discussion
Sunday, February 9, 2014
07:30:00 Breakfast
09:00:00 Proteolytic Functions in Physiology and Disease Katerina Akkasoglou, Erik Martin
09:05:00 Prostasin (CAP1/PRSS8) supports epidermal development and postnatal survival independent of its catalytic activity
09:15:00 Discussion
09:20:00 Inflammation-induced loss of the Prostasin-Matriptase barrier promoting pathway in intestinal epithelium contributes to the pathogenesis of colitis Marguerite Buzza
09:35:00 Discussion
09:40:00 Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis
09:55:00 Discussion
10:00:00 Targeting a novel bone degradation pathway in osteosarcoma
10:15:00 Discussion
10:20:00 The role of PAI-1 and NO in aging-related pathology in mice
10:35:00 Discussion
10:40:00 Development of a sandwich-type ELISA for the detection of human active thrombin activatable fibrinolysis inhibitor (TAFIa) and assessment in patients Maarten Hendrickx
10:55:00 Discussion
11:00:00 Poster Session II (even-numbered posters)
12:30:00 Lunch
13:30:00 Proteolytic Functions in Physiology and Disease (continued) Katerina Akkasoglou
13:35:00 Dual targeting of TAFI and PAI-1 as a novel treatment for acute ischemic stroke Tine Wyseure
13:45:00 Discussion
13:50:00 Investigation into the Mechanisms of LRP1-mediated FVIII Clearance
14:05:00 Discussion
14:10:00 Macrophage LRP1 Modulates Lipid Homeostasis and Diet-Induced Hepatic Inflammation
14:25:00 Discussion
14:30:00 The Plasminogen Receptor S100A10 Modulates Plasmin-mediated Fibrinolysis in Acute Promyelocytic Leukemia
14:45:00 Discussion
14:50:00 Evaluation Period
15:00:00 Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.
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