EFMC-ISMC 2014 - XXIII International Symposium on Medicinal Chemistry

Lisbon, Portugal
EFMC-ISMC 2014 - XXIII International Symposium on Medicinal Chemistry 

Schedule of Presentations:

Sunday, September 7, 2014
16:15:00 Opening Ceremony
16:35:00 Portugal: the Right Place to build Partnerships in Health Joaquim CUNHA
16:50:00 Partnership between Public and Private Sources: Pharma and IMI Perspective
17:10:00 EFMC Award Ceremony
17:25:00 The Nauta Award for Pharmacochemistry Pursuing Compound Quality Paul Gleeson
18:10:00 The Ubiquitin Proteolytic System - From Basic Mechanisms Through Human Diseases And On To Drug Development Aaron Ciechanover
19:00:00 Welcome Reception
Monday, September 8, 2014
06:00:00 New Presentation Phil Jones
08:30:00 The UCB-Ehrlich Award for Excellence in Medicinal Chemistry Small Molecule Control Of Intracellular Protein Levels Craig M Crews
09:15:00 The Prous Institute-Overton and Meyer Award for New Technologies i Drug Discovery Thermodynamics Assisted Drug Discovery György G. FERENCZY
10:00:00 Exhibition & Coffee
10:30:00 Session Chair Helmut GRUBMÜLLER
10:35:00 Mechanoenzymatics of Biomolecular Machines: Free Energies, Dynamics, Function Helmut GRUBMÜLLER
10:35:00 Recent Advances In Asymmetric Catalysis Erick M. CARREIRA
10:35:00 Inflammation, Obesity and Metabolic Disease Ajay Chawla
11:15:00 CB2 Agonists Protect from Inflammation Related Kidney Damage and Fibrosis Uwe GRETHER
11:15:00 New Stereoselective Organocatalytic Reactions for the Synthesis of Isoquinoline Alkaloids Pier Giorgio COZZI
11:15:00 Efficient Determination Of Protein-Ligand Standard Binding Free Energies And Permeabilities With A Computational Microcalorimeter Chris CHIPOT
11:35:00 The Discovery of APD334, a Selective S1P1 Functional Antagonist Robert Jones
11:35:00 Binding Affinity Prediction from Molecular Simulation – Soon a Standard Method in Structure-Based Drug Design?
11:35:00 Metalation of Polyfunctional Heterocyclic Compounds: Applications in Agrochemistry
11:55:00 P-Glycoprotein/Membrane Role on Multidrug Resistance: Insights from In Silico Studies Ricardo Ferreira
11:55:00 Discovery of Small Molecule Rorγ Modulators for the Treatment of Autoimmune Diseases Frank Narjes
11:55:00 Development of Novel Building Blocks to Accelerate Drug Discovery Pavel Mykhailiuk
12:15:00 Exhibition & Lunch
13:15:00 Session Chair Ada Yonath
13:20:00 Aminoglycoside Mechanisms of Action, Resistance and Toxicity – Prospects for Antibiotic Drug Development
14:00:00 Visualising Novel Macrolide Antibiotics Bound to Their Ribosomal Target Stephen DOUTHWAITE
14:20:00 The Ribosome as a Drug Target: Insights from Structural Investigations - Towards Rational Drug Design
14:40:00 Antagonists of the Pseudomonas Quinolone Signal Receptor (PQSR) as Promising Anti-Virulence Agents
15:00:00 Exhibition & Coffee
15:30:00 MedChemComm Prize Winner : Phage Selection Of Bicyclic Peptides For Therapeutic Application Christian Heinis
16:00:00 The Open Phacts Discovery Platform - Semantic Data Integration For Medicinal Chemists Gerhard Ecker
16:30:00 European Lead Factory - Game Changing For Innovative Medicines
17:00:00 Funding Opportunities with the Innovative Medicines Initiative 2
17:30:00 Poster Session I and Networking
19:30:00 End of the day
20:30:00 Concert (free of charge, but subject to registration
Tuesday, September 9, 2014
08:30:00 Prize Ceremony
08:35:00 EFMC Prize for a Young Medicinal Chemist in Industry Design, Synthesis and Properties of Potent Inhibitors of Pseudomonas Aeruginosa Deacetylase LpxC
08:55:00 EFMC Prize for a Young Medicinal Chemist in Academia Inhibitors and Substrates of the Human Lysine Deacylase Enzymes Christian A. Olsen
09:15:00 Innovation To Create Value For Patients Ismail KOLA
10:00:00 Exhibition & Coffee
10:30:00 Session Chair Samuel BONACORSI
10:35:00 PET Imaging: Synthesis of Radiopharmaceuticals and their Application in Personalized Medicine and Drug Discovery Peter J.H. Scott
11:15:00 A Rational Approach to the Development of Radioligands and PET Ligands for Drug Development Chad ELMORE
11:35:00 Design, Synthesis and Development of Lysophosphatidic Acid Receptor 1 (LPA1) PET Radioligands for Lung Receptor Occupancy Imaging Samuel BONACORSI
11:55:00 Quantitative Imaging of Mglu5 Allosteric Binding Site and its Occupancy by Positron Emission Tomography with The Novel Fluorine-18 Labelled Probe [18f]Pss232 Stefanie Kramer
12:15:00 Exhibition & Lunch
13:15:00 Session Chair
13:20:00 Therapeutic Opportunities Offered by the Excessive Lactate Production in Cancer Filippo MINUTOLO
14:00:00 Novel Anti-Cancer Treatment Targeting Vps34
14:20:00 Exploiting Tumor Metabolic Vulnerabilities with Novel OxPhos Inhibitors
14:40:00 Discovery and Characterization of A-366, a Novel, Potent and Highly Selective Inhibitor of Histone Methyltransferase G9a
15:00:00 Exhibition & Coffee
15:30:00 Medicinal Chemistry Experts in Pharma are Helping us to Generate Freely Available Novel Probes in Order to Facilitate Target Discovery Chas Bountra
16:30:00 Poster Session II and Networking
18:30:00 End of the day
Wednesday, September 10, 2014
02:00:00 Design, Synthesis and Biological Evaluation of Potent and Selective Class IIA Histone Deacetylase Inhibitors as a Potential Therapy for Huntington's Disease
02:40:00 Novel Potent Inhibitors of the Histone Demethylase KDM1A
09:15:00 Plenary Session
10:00:00 Exhibition & Coffee
10:30:00 Session Chair
10:35:00 Cyclic Peptides from the nature to the synthetic ones Fernando Albericio
11:15:00 Successful Drug Discovery And Development Case Studies Of Protein Epitope Mimetics Daniel Obrecht
11:35:00 Invited Lecture
11:55:00 Novel Inhibitors of Alzheimer's Associated Beta-Secretase-Clusters of Heparan Sulfate
12:15:00 Exhibition & Lunch
13:15:00 Session Chair
13:20:00 Cebranopadol, a Novel, Potent Analgesic
13:40:00 Discovery of BAY 1002670 - A Highly Potent and Selective Progesterone Receptor Modulator for Gynecological Therapies
14:20:00 Structure-Guided Design of Potent, Selective, Orally Bioavailable Tankyrase Inhibitors Erin Dimauro
15:00:00 Excursions
20:00:00 Banquet
20:30:00 IUPAC Richter Prize Lecture Medicinal Chemistry, Quo Vadis? - The Changing Climate In R&D
Thursday, September 11, 2014
06:00:00 New Presentation
06:00:00 New Presentation
06:00:00 New Presentation
06:00:00 New Presentation
08:30:00 Session Chair Jan Steyaert
08:35:00 High End Design for GPCRs: Combining Protein Structure, Biophysical Data and Computational Water Network Energies Jonathan Mason
09:15:00 Nanobody-Enabled Fragment Screening On Active-State Constrained GPCRs Jan Steyaert
09:35:00 Covalent Agonists Facilitating Crystallisation of GPCRs Peter Gmeiner
09:55:00 Crystallographic Structures Enable the Discovery of Selective 5-Ht1b Receptor Ligands through Virtual Screening
10:15:00 Exhibition & Coffee & Snacks
10:45:00 Session Chair
10:50:00 CHF-6001, an Inhaled PDE4 Inhibitor for Asthma and COPD: Synthesis, In Vitro and In Vivo Characterization
11:10:00 The Discovery of AZD5069; a CXCR2 Antagonist In Phase II Clinical Trials for the Treatment of Asthma Rhona Cox
11:30:00 Discovery of BAY 85-8501, a Novel and Highly Potent Induced-Fit Binder of Human Neutrophil Elastase for Pulmonary Diseases
11:50:00 Discovery of TD-5959 (Batefenterol/GSK-961081): A First-in-Class Dual Pharmacology Multivalent Muscarinic Antagonist and Beta-2 Agonist (MABA) for the Treatment of COPD
12:10:00 Identifying Selective Inhibitors of FGFR4 Kinase Kurt Pike
12:30:00 Closing Lecture Personalised Medicinal Systems Chemistry Hans WESTERHOFF
13:15:00 Closing Remarks, Poster Prizes and Welcome to EFMC-ISMC 2016
3D Tissue Models
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