The Royal Garden Hotel
London, United Kingdom
London, mm
knowledge sharing in CNS: sampling and visualising chemical-biological space

Approaches to analysing high throughput screening data 
Data reduction to a humanely interpretable form 
Utilising video walls and data visualisation tools

Schedule of Presentations:

Tuesday, October 23, 2007
07:00:00 Presenters L E Schechter, Anne Bruinvels, Eric Parker, Alfred T Sapse, Aaron Chuang, John Sinden, Michael McDonald, Henrik Klitgaard,, Alan Palmer, Lars Sundstrom,, Mark Treherne, Bengt von Mentzer, Klaus Mendla, Michael J O Neill, Thomas Steckler, Karin Sandager Nielsen, Antony Altar, Richard Wise, Anders Haegerstrand, John Mordock, Nicholas Moore, Stafford Lightman, John Kemp, Trevor Howe, Russell Hagan, Ronan Depoortere, Shaun Jordan,
08:00:00 Registration and coffee
09:00:00 Chairman’s opening remarks
09:15:00 Keynote address: knowledge sharing in CNS: sampling and visualising chemical-biological space
09:45:00 Keynote address: biomarkers for CNS disease: from genetics to therapeutics
10:15:00 Preliminary results of a novel diagnostic test as a key biomarker for CNS disorders
10:45:00 Morning coffee
11:30:00 The role of FMRI in drug discovery
12:00:00 Panel session: what makes the most effective biomarkers and what alternative methods are available?
12:45:00 Lunch
14:15:00 Integrating biomarkers into the development of disease-modifying therapies for Alzheimer’s disease
14:45:00 Receptor interaction possibilities for treatment of CNS disorders
15:15:00 Afternoon tea
16:00:00 Application of 3D in-vitro platforms for lead optimisation studies
16:30:00 Addressing continuing unmet needs with improved symptomatic therapies for neurological diseases
17:00:00 Chairman’s closing remarks
Wednesday, October 24, 2007
08:00:00 Registration and coffee
08:45:00 Chairman’s opening remarks
09:00:00 Keynote address: neural stem cells as drug targets for neurodegenerative diseases
09:30:00 Activating the endogenous stem cells with drugs: a novel approach in clinical trials
10:00:00 CNS disorders as post traumatic stress diseases (PTSD)
10:30:00 Morning coffee
11:45:00 Panel session: key successes in stem cell therapies and where do we go from here?
12:30:00 Speed networking
13:15:00 Lunch
15:15:00 Gene therapy for neurodegenerative diseases: an AAV genetic delivery mechanism
15:45:00 Increasing dopamine synthesis in Parkinson’s disease via gene therapy
15:45:00 Attacking beta amyloid accumulation: Alzheimer’s antibodies
16:45:00 Afternoon tea
16:45:00 Secretase inhibitors for the treatment of alzheimer's disease: the cutting edge or cutting it too close?
17:15:00 Recent progress and major challenges in the search for disease modifying therapies for Parkinson’s disease
17:45:00 Neuroprotective targets in excitotoxicity – the postsynaptic density and beyond
18:15:00 Chairman’s closing remarks
18:25:00 Networking drinks reception
Thursday, October 25, 2007
08:00:00 Registration and coffee
08:45:00 Chairman’s opening remarks
09:00:00 Keynote address: drug development for psychiatric disorders in the future: an overview of the challenges, strategies and approaches for the treatment of mood disorders
09:30:00 Future trends in anti-depression treatments
10:00:00 The potential of a vaccination for depression
10:30:00 Morning coffee
11:15:00 Drug discovery for psychiatric conditions: targeting the HPA axis
11:45:00 Strategies for the development of antipsychotics: a review of recent approaches with a focus on third generation compounds combining activity at dopamine D2 and 5-HT1A receptors
12:15:00 Mechanism of action of dopamine system stabilisers
12:45:00 Lunch
14:15:00 Dopamine D3 receptor antagonism as a potential therapeutic target for treating schizophrenia
14:45:00 Enhancing NMDA receptor function in Schizophrenia
16:00:00 Afternoon tea
16:30:00 SV2A selective drugs: a new approach for the treatment of epilepsy
17:00:00 Metabotropic glutamate receptors as targets for therapeutic interventions in CNS disorders
17:30:00 A breakthrough in delivering compounds across the blood-brain barrier
18:00:00 Chairman’s closing remarks
3D Tissue Models
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