The Ubiquitin System: Biology, Mechanisms and Roles in Disease
HOTEL CROATIA CAVTAT
Frankopanska 10
Cavtat-Dubrovnik, Croatia
http://meetings.embo.org/event/19-ubiquitin-system
The Ubiquitin System: Biology, Mechanisms and Roles in Disease
ZMBH
http://meetings.embo.org/event/19-ubiquitin-system
HOTEL CROATIA CAVTAT
Frankopanska 10 
Cavtat-Dubrovnik
Croatia

Schedule of Presentations:

Friday, September 13, 2019
15:30:00 Arrival and Registration
17:30:00 Welcome treats
18:00:00 Opening and welcome Claudio Joazeiro
18:15:00 Keynote Lecture Ivan Dikic
19:00:00 Toxin-Antitoxin Modules Drive Reproductive Manipulation by Intracellular Wolbachia Bacteria Mark Hochstrasser
19:30:00 Regulating Regulation by the Pup-Proteasome System Heran Darwin
20:00:00 Pupylation and its Connection to the Mycobacterial DNA Damage Response Eilika Weber-Ban
20:30:00 Dinner
Saturday, September 14, 2019
06:00:00 New Presentation
06:00:00 New Presentation
09:00:00 Ubiquitin-like modifications during development: from organs to organelles Rosa Barrio
09:30:00 SUMOylation in signal transduction Frauke Melchior
10:00:00 Regulation of SUMO conjugation Andrea Pichler
10:20:00 High levels of the Interferon-Stimulated Gene 15 – ISG15 – promote unrestrained DNA replication and chromosomal breakage via deregulated fork restart
10:35:00 Role of RNF4 in SUMO-dependent, ubiquitin-mediated protein degradation
11:05:00 COFFEE BREAK
11:30:00 Architecture and activities of a multi-subunit SUMO ligase complex
12:00:00 PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network Raymond J. Deshaies
12:30:00 How a ubiquitin-like protein brings ubiquitylation to life Brenda Schulman
12:45:00 Ancestral Origins of Ribosome-Associated Quality Control Claudio Joazeiro
13:00:00 Ubiquitin Transfer Mechanisms for RING-Cys-Relay E3 Ligases
13:15:00 Structure of the Fanconi anemia monoUb ligase complex
13:30:00 Lunch and meet with the experts tables (editors, pharma, speakers)01
15:00:00 Understanding selective autophagy
15:30:00 Regulation of mitophagy by lipid-binding proteins
16:00:00 DNA damage detection in nucleosomes involves DNA register shifting Nico Thomae
16:30:00 COFFEE BREAK
16:50:00 Contributions made to the proteasome by substrate receptors Kylie Walters
17:20:00 Regulation of the 20S proteasome by a novel family of inhibitory proteins Michal Sharon
17:50:00 Global views of degradation in cancer Yifat Merbl
18:20:00 The human proteasome: new insights into its regulation
18:35:00 Poster Session I
Sunday, September 15, 2019
09:00:00 Function and regulation of E3 ligases during cell growth and division Matthias Peter
09:30:00 RPL26 UFMylation and protein biogenesis in the endoplasmic reticulum Ron Kopito
10:00:00 Ribosome Heterogeneity in Translating the Genetic Code Maria Barna
11:00:00 C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases Hsueh-Chi Sherry Yen
11:30:00 An evolutionary principle of cellular robustness
12:00:00 Mechanisms of protein quality control in the cytosol Manu Hegde
12:30:00 Site-specific ribosome deubiquitination by G3BP1–USP10 prevents turnover of stalled ribosomes
13:00:00 Chemoenzymatic site-specific ubiquityl- and SUMOylation in vitro and in cells
13:15:00 Lunch and meet with the experts tables (editors, pharma, speakers)
15:00:00 Excursion to Dubrovnik
Monday, September 16, 2019
06:00:00 New Presentation
09:00:00 Nrf2 activation promotes lung cancer metastasis by inhibiting the Fbxo22-dependent degradation of Bach1 Michele Pagano
09:30:00 Compartmentalization of ubiquitination via phase separation Tanja Mittag
10:00:00 DUB gymnastics: how intrinsic allostery and the substrate collaborate to activity Titia K. Sixma
10:30:00 Coffee break
11:00:00 Ubiquitin Tips the Balance: Impact of Food Perception on Protein Quality Control & Aging Thorsten Hoppe
11:30:00 ER-Associated Degradation (ERAD) Thomas Sommer
12:00:00 Mechanism of ER-associated protein degradation (ERAD) Tom Rapoport
12:30:00 The E3 Doa10 facilitates retrotranslocation in ERAD Alexander Steinbüchel
12:45:00 Sporadic Alzheimer's disease – does it start with altered Ub signalling? Richard Glickman-Simon
13:00:00 Lunch and meet with the experts tables (editors, pharma, speakers)
14:30:00 Functional aggregates in innate immunity Sun Hur
15:00:00 Nedd4 E3 ligases in cancer and neurodegeneration Simona Polo
15:30:00 EMBO Young Investigator: Regulation of ubiquitin signalling by DUBs Yogesh Kulathu
16:00:00 COFFEE BREAK
16:30:00 Ubiquitin-dependent control of developmental and stress signaling
17:00:00 SUMO and Ubiquitin proteases in Replication Jo Morris
17:30:00 The SUMO-targeted ubiquitin network is intertwined with the dynamics of cytoplasmic stress granules Stefan O Mueller
17:45:00 Systematic discovery of new DUB classes in host and pathogen genomes
18:00:00 Poster session II
21:00:00 Party and award ceremony
Tuesday, September 17, 2019
06:00:00 New Presentation
06:00:00 New Presentation
06:00:00 New Presentation
06:00:00 New Presentation
06:00:00 New Presentation
06:00:00 New Presentation
06:00:00 New Presentation
09:00:00 UFMylation is required for translational homeostasis and cell cycle progression
09:30:00 Ubiquitin System Chemistry Huib Ovaa
10:00:00 Drugging the Malaria Parasite Proteasome
10:30:00 COFFEE BREAK
10:45:00 The poly-SUMO2/3 protease SENP6 enables assembly of the constitutive centromere-associated network by group deSUMOylation
11:15:00 The impact of E3 ligase selection in Targeted Protein Degradation drug discovery David F. Townson
11:30:00 A PROTAC approach for targeting E3 ligases for cancer treatment
11:45:00 Closing: final remarks
12:00:00 Lunch or boxed lunch
3D Tissue Models
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