3D Tissue Models
4th International Conference on Tumor Progression & Therapeutic Resistance
Loews Philadelphia Hotel
1200 Market Street
Philadelphia, PA

Event Sponsors

Schedule of Presentations:

Thursday, October 4, 2007
07:00:00 Registration & Breakfast
07:50:00 Welcome and Opening Remarks
08:00:00 Beyond the VEGF Trap: Veloci-Technologies Identify Dll4 as the Next Angiogenesis Target
08:45:00 Building on Progress: The Next Generation of Oncology Therapeutics in Clinical Context
09:30:00 Combinatorial Approaches to Molecular Targeted Therapies: Rationale for Multi-Targeting in Cancer
10:00:00 Networking & Refreshment Break
10:30:00 A Human Monoclonal Antibody Drug Conjugate against EphA2 Inhibits Tumor Growth In Vivo
11:00:00 Targeted Therapy for Amplified Receptor Tyrosine Kinases in Cancer
11:30:00 Mechanistic Implications of TGFBeta Signaling in Pancreatic Cancer
12:00:00 Luncheon
13:00:00 Overcoming Resistance to Inhibitors of the Mitotic Kinesin KSP
13:30:00 SARMs: Prevention of Bone and Muscle Loss with Antagonism in Prostate - Implication in Prostate Cancer and Benign Prostate Hyperplasia
14:00:00 TBA
14:30:00 Lenalidomide and Pomalidomide Inhibit the Proliferation of Malignant B Cells While Expanding Normal CD34+ Progenitor Cells
15:00:00 JNJ-26481585 is Novel “Second Generation” Oral pan-Histone Deacetylase (HDAC) Inhibitor with Broad-Spectrum Preclinical Antitumoral Activity against Solid and Haematological Malignancies
15:30:00 Networking and Refreshment Break
16:00:00 Translating the Outcome of MLN8054-mediated Aurora A Inhibition Characterized in Cultured Human Tumor Cells into Clinically Relevant Pharmacodynamic Assays
16:30:00 High Resolution Detection of Chromosomal Changes in Frozen and FFPE Tumor Tissue
17:00:00 New Molecular Probe for Characterization of HER2 Expression In Vivo
17:30:00 Identification and Development of Biomarkers that Predict Clinical Response to the Histone Deacetylase Inhibitor Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA, Zolinza™)
18:00:00 Close of Day One, Poster Session & Networking Reception
Friday, October 5, 2007
07:00:00 Continental Breakfast
08:00:00 Cancer Cytogenetics: Chromosomal Clues to Complexity
08:30:00 Mouse Modeling of Genetic and Reproductive Factors in Ovarian Cancer Development
09:00:00 pRb2/p130 and Epigenetic Modifications in Cancer: A Novel Cross-Talk
09:30:00 Hypoxia, Stem Cells, and Cancer
10:00:00 Networking and Refreshment Break
10:30:00 Pre-metastatic Niche: The Role of Hematopoietic Progenitors in Cancer Metastasis
11:00:00 The Characterization of Novel Anti-Metastatic Strategies
11:30:00 New Signaling Mechanisms Governing Invasion and Metastasis in Vivo
12:00:00 Luncheon
13:00:00 Oral Presentations from Submitted Abstracts
13:30:00 Targeting Neuropilin-1 to Inhibit Tumor Growth
14:00:00 Role of Stromal & Vascular Cells & Related Cytokines in Therapeutic Resistance
14:30:00 Bosutinib: From Lowly Yeast to Clinical Trials
15:00:00 Conference Concludes
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