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Peer Reviewed Papers, Books, Chapters

Year Title Citation Authors Review type Summary Keywords File filename File mime type
1. 2012 A review of computational tools to study and predict protein and biotherapeutic aggregation in preparation
2. 2012 A flexible-protein molecular docking study of the binding of ruthenium complex compounds to PIM1, GSK-3β, and CDK2/Cyclin A protein kinases submitted.
3. 2012 The biology and physics of clathrin-mediated endocytosis, submitted.
4. 2012 Monte Carlo simulations of vascular drug delivery using spherical nanocarriers submitted.
5. 2012 A high-throughput predictive tool for modeling long-term antibody aggregation in preparation
6. 2010 Protein-mediated orchestration of vesiculation prior to vesicle-scission in clathrin-dependent endocytosis, PLoS Comp. Biol. 2010, 6(9), e1000926.
7. 2010 Protein-mediated orchestration of vesiculation prior to vesicle-scission in clathrin-dependent endocytosis PLoS Comp. Biol., 6(9), e1000926
8. 2009 Calculation of free energies in fluid membranes subject to heterogeneous curvature fields Phys. Rev. E, 80, 011925.
9. 2009 Calculation of free energies in fluid membranes subject to heterogeneous curvature fields, Phys Rev. E 2009, 80, 011925.
10. 2009 The solubility of carbon dioxide and hydrogen sulfide in aqueous N-methyldiethanolamine solutions Ind. Eng. Chem. Res., 2009, 48(8), 4051.
11. 2009 The solubility of carbon dioxide and hydrogen sulfide in aqueous N-methyldiethanolamine solutions Ind. Eng. Chem. Res., 2009, 48(8), 4051.
12. 2008 Geometry of mediating protein affects the probability of loop formation in DNA Biophys. J. 2008, 94, 3150
13. 2008 The solubility of carbon dioxide in aqueous N-methyldiethanolamine solutions Fluid Phase Equilib. 2008, 264, 99
14. 2008 Geometry of mediating protein affects the probability of loop formation in DNA Biophys. J., 94, 3150
15. 2008 The solubility of hydrogen sulfide in aqueous N-methyldiethanolamine solutions Int. J. Oil, Gas and Coal Technology., 1(4), 399
16. 2008 The solubility of hydrogen sulfide in aqueous N-methyldiethanolamine solutions, Int. J. Oil, Gas and Coal Technology., 2008, 1(4), 399
17. 2008 The solubility of carbon dioxide in aqueous N-methyldiethanolamine solutions. Fluid Phase Equilib. 2008, 264, 99.
18. 2007 Gas solubility of H2S and CO2 in aqueous solutions of N-methyldiethanolamine. J. Pet. Sci. Eng. 2007, 55, 122.
19. 2007 Role of glycocalyx in mediating nanocarrier cell adhesion explored using a thermodynamic model and Monte Carlo simulations J. Phys. Chem. C, 111, 15848.
20. 2007 A Multiscale computational approach to dissect early events in the Erb family receptor mediated activation, differential signaling, and relevance to oncogenic transformations Ann. Biomed. Eng., 35, 1012
21. 2007 Gas solubility of H2S and CO2 in aqueous solutions of N-methyldiethanolamine J. Pet. Sci. Eng., 55, 122
22. 2007 Role of glycocalyx in mediating nanocarrier cell adhesion explored using a thermodynamic model and Monte Carlo simulations J. Phys. Chem. C 2007, 111, 15848
23. 2007 A Multiscale computational approach to dissect early events in the Erb family receptor mediated activation, differential signaling, and relevance to oncogenic transformations. Ann. Biomed. Eng. 2007, 35, 1012.
24. Minimal residual disease is currently the most powerful prognostic indicator in Precursor B lymphoblastic leukemia. Pubmed Minimal residual disease is currently the most powerful prognostic indicator in Precursor B lymphoblastic leukemia. Multiparameter flow cytometry is the most commonly used modality. Seventy three B ALL cases and 15 normal marrows were evaluated for expression patterns of leukemia markers (CD38, CD58, CD73) in all 73 cases and CD66c, CD86 and CD123 in 23 cases. CD73 was aberrantly expressed in 90.41% cases and CD86 in 60.87% B ALL cases. Thus addition of these markers in MRD panels can increase the sensitivity of the assay. Acute leukemia; Hematology; MRD
25. Pubmed
26. Though adoptive tumor-infiltrating lymphocyte (TIL) therapy has been explored in clinical trials for many years, there is little information for the clonotype composition between TILs in original tumor tissues and TILs that were in vitro expanded and infused to cancer patients. Pubmed Though adoptive tumor-infiltrating lymphocyte (TIL) therapy has been explored in clinical trials for many years, there is little information for the clonotype composition between TILs in original tumor tissues and TILs that were in vitro expanded and infused to cancer patients. To investigate the similarity/difference in TILs in original tumor tissues and those of in vitro expanded populations in squamous cell carcinoma of head and neck (SCCHN) as well as their correlation with somatic mutations in cancer cells, we performed whole exome analysis, expression profile analysis of immune-related genes, and T cell receptor (TCR) analysis of original TILs and in vitro expanded TILs in 8 surgically-resected HPV-negative fresh tumors with SCCHN. We found an unusually high number of non-synonymous somatic mutations (4290, 1779 and 901 mutations) in three SCCHN tumors, in which we identified mutations in mismatch repair genes, MSH2 or MSH4, or a DNA polymerase gene, POLE. Interestingly, dominant TCR clonotypes of expanded CD8+ TILs derived from these three tumors revealed high similarity to those in original tumors while for remaining tumors with the lower mutational load, we found that T cell clonotypes between TILs in original tumor tissues and those expanded in vitro were almost entirely different. Our findings might provide clinically useful information for identification of tumor-antigen-specific T cell clones that may lead to further improvement of adoptive TIL therapy for SCCHN patients. T cell receptor; mismatch repair; non-synonymous mutation; squamous cell carcinoma of head and neck cancer; tumor-infiltrating lymphocytes


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