3D Tissue Models

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Peer Reviewed Papers, Books, Chapters

Year Title Citation Authors Review type Summary Keywords File filename File mime type
1. 2011 AOT vesicles as templates for the horseradish peroxidase-triggered polymerization of aniline Soft Matter, in press, DOI: 10.1039/C0SM00599A
2. 2010 3D structural analysis of eukaryotic flagella/cilia by electron cryo-tomography J. Synchrotron Radiation, in press
3. 2010 ) Local and global mobility in the ClpA AAA+ chaperone detected by cryo-electron microscopy: functional connotations Structure 18, 553-562.
4. 2010 Novel type of bicellar disks from a mixture of DMPC and DMPE-DTPA with complexed lanthanides Langmuir, 26, 5382-5387
5. 2010 Molecular details of Bax activation, oligomerization and membrane insertion J. Biol. Chem. 285, 6636-6647
6. 2010 Magnetic field alignable domains in phospholipid vesicle membranes containing lanthanides J. Phys. Chem. B 114, 174-186
7. 2010 3D structural analysis of eukaryotic flagella/cilia by electron cryo-tomography J. Synchrotron Radiation, in press
8. 2010 Global conformational changes of dynein arms in flagella induced by nucleotides Nat. Struct. Mol. Biol., 17, 761-767.
9. 2010 Magnetic field alignable domains in phospholipid vesicle membranes containing lanthanides J. Phys. Chem. B 114, 174-186.
10. 2010 Molecular details of Bax activation, oligomerization and membrane insertion J. Biol. Chem. 285, 6636-6647
11. 2010 ) Novel type of bicellar disks from a mixture of DMPC and DMPE-DTPA with complexed lanthanides Langmuir, 26, 5382-5387
12. 2010 Global conformational changes of dynein arms in flagella induced by nucleotides Nat. Struct. Mol. Biol., 17, 761-767.
13. 2010 Local and global mobility in the ClpA AAA+ chaperone detected by cryo-electron microscopy: functional connotations Structure 18, 553-562.
14. 2009 Asymmetry of inner dynein arms and inter-doublet links in Chlamydomonas flagella J. Cell Biol. 186, 437-446.
15. 2009 Asymmetry of inner dynein arms and inter-doublet links in Chlamydomonas flagella J. Cell Biol. 186, 437-446.
16. 2009 Vesicles as soft templates for the enzymatic polymerization on aniline Langmuir, 25, 11390-11405
17. 2008 Molecular architecture of inner dynein arms in situ in Chlamydomonas flagella J. Cell Biol., 183, 923-932.
18. 2008 pH-sensitive vesicles containing a lipidic beta-amino acid with two hydrophobic chains Chem. Biodivers. 5, 16-30
19. 2008 Reconstruction of pilus assembly reveals a bacterial outer membrane catalyst Science 320, 376-379.
20. 2008 Temperature-sensitive nonionic vesicles prepared from Span 80 (sorbitan monooleate) Langmuir, 24, 10762-10770.
21. 2008 Vesicle formation from reactive surfactants Angew. Chem. Int. Ed. Engl. 47, 1323-1325
22. 2007 Vesicles from docosahexaenoic acid Colloids Surf. B Biointerfaces 54, 118-123
23. 2007 The architecture of outer dynein arms in situ J. Mol. Biol. 368, 1249-1258
24. 2006 Structure of the E. coli signal recognition particle bound to a translating ribosome Nature 444, 503-506.
25. 2004 Subdomain organization of the Acanthamoeba myosin IC tail from cryo-electron microscopy Proc. Natl. Acad. Sci. USA 101, 12189-12194.
26. 2004 The N-terminal substrate-binding domain of ClpA unfoldase is highly mobile and extends axially from the distal surface of ClpAP protease J. Struct. Biol. 146, 180-188
27. 2002 Structural and enzymatic properties of the AAA Protein Drg1p from Saccharomyces cerevisiae. Decoupling of intracellular function from ATPase activity and hexamerization J. Biol. Chem. 277, 26788-26795.
28. 2002 The two actin-binding regions on the myosin heads of cardiac muscle Biochemistry 41, 5429-5438.
29. 2001 Ca(2+)-induced switching of troponin and tropomyosin on actin filaments as revealed by electron cryo-microscopy J. Mol. Biol. 308, 241-261
30. 2001 Translocation pathway of protein substrates in ClpAP protease Proc. Natl. Acad. Sci. USA 98, 4328-33.
31. 2001 Functional domains of the ClpA and ClpX molecular chaperones identified by limited proteolysis and deletion analysis J. Biol. Chem. 276, 29420-29429
32. 2000 Docking of components in a bacterial complex Nature 408, 667-668.
33. 2000 Visualization of substrate binding and translocation by the ATP-dependent protease,ClpXP Mol. Cell 6, 1515-1521
34. 1999 Calcium-induced changes in the location and conformation of troponin in skeletal muscle thin filaments J. Biochem. (Tokyo) 126, 200-211.
35. 1999 Three- Dimensional Electron Microscopy of the Photosystem II Core Complex J. Struct. Biol. 123, 211-224.
36. 1995 Threedimensional structure of the kinesin head-microtubule complex Nature 376, 274-277
37. 1995 Proposal of alignment-independent classification of electron microscopic images with helical symmetry and its application to reconstituted thin filament of skeletal muscle Ultramicroscopy 57, 91-101.
38. 1994 Direct visualization of the microtubule lattice seam both in vitro and in vivo J. Cell Biol. 127, 1965-1971.
39. 1994 Calcium induced change in three-dimesional structure of thin filaments of rabbit skeletal muscle as revealed by cryo-elecron miscroscopy Biochem. Biophys. Res. Commun. 203, 951-958.
40. Cancer cells alter their metabolism for the production of precursors of macromolecules. Pubmed Cancer cells alter their metabolism for the production of precursors of macromolecules. However, the control mechanisms underlying this reprogramming are poorly understood. Here we show that metabolic reprogramming of colorectal cancer is caused chiefly by aberrant MYC expression. Multiomics-based analyses of paired normal and tumor tissues from 275 patients with colorectal cancer revealed that metabolic alterations occur at the adenoma stage of carcinogenesis, in a manner not associated with specific gene mutations involved in colorectal carcinogenesis. MYC expression induced at least 215 metabolic reactions by changing the expression levels of 121 metabolic genes and 39 transporter genes. Further, MYC negatively regulated the expression of genes involved in mitochondrial biogenesis and maintenance but positively regulated genes involved in DNA and histone methylation. Knockdown of MYC in colorectal cancer cells reset the altered metabolism and suppressed cell growth. Moreover, inhibition of MYC target pyrimidine synthesis genes such as CAD, UMPS, and CTPS blocked cell growth, and thus are potential targets for colorectal cancer therapy. MYC; colorectal cancer; metabolism; metabolomics; omics


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