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Peer Reviewed Papers, Books, Chapters

Year Title Citation Authors Review type Summary Keywords File filename File mime type
1. 2013 Optimisation and validation of a high throughput screening compatible assay to identify inhibitors of the plasma membrane calcium ATPase pump - a novel therapeutic target for contraception and malaria J Pharm Pharm Sci, 16(2), 217-30. eScholarID:205389 | PMID:23958191
2. 2013 Development and characterization of a novel fluorescent indicator protein PMCA4-GCaMP2 in cardiomyocytes J Mol Cell Cardiol, eScholarID:202449 | PMID:23880607 | DOI:10.1016/j.yjmcc.2013.07.007
3. 2012 Disruption of the interaction between PMCA2 and calcineurin triggers apoptosis and enhances paclitaxel-induced cytotoxicity in breast cancer cells Carcinogenesis, eScholarID:170202 | PMID:22962307 | DOI:10.1093/carcin/bgs282
4. 2011 Local signals with global impacts and clinical implications: lessons from the plasma membrane calcium pump (PMCA4) Biochim Biophys Acta, 1813(5), 974-8. eScholarID:128506 | PMID:21167220 | DOI:10.1016/j.bbamcr.2010.12.007
5. 2011 Calcium signaling dysfunction in heart disease Biofactors, 37(3), 175-81. eScholarID:128505 | PMID:21674639 | DOI:10.1002/biof.149
6. 2011 Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury Am J Physiol Heart Circ Physiol, eScholarID:128507 | PMID:21705677 | DOI:10.1152/ajpheart.01003.2010
7. 2011 Plasma membrane calcium pump (PMCA4)/neuronal nitric oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain J Biol Chem, eScholarID:134851 | PMID:21965681 | DOI:10.1074/jbc.M111.290411
8. 2010 Endothelial nitric oxide synthase activity is inhibited by the plasma membrane calcium ATPase in human endothelial cells Cardiovasc Res, eScholarID:79049 | PMID:20211863 | DOI:10.1093/cvr/cvq077
9. 2010 FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling J Mol Cell Cardiol, eScholarID:75756 | PMID:19852968 | DOI:10.1016/j.yjmcc.2009.10.009
10. 2010 Measurement of plasma membrane calcium-calmodulin-dependent ATPase (PMCA) activity Methods Mol Biol, 637, 333-42. eScholarID:80248 | PMID:20419444 | DOI:10.1007/978-1-60761-700-6_18
11. 2009 Tumor suppressor Ras-association domain family 1 isoform A is a novel regulator of cardiac hypertrophy Circulation, 120(7), 607-16. eScholarID:75757 | PMID:19652091 | DOI:10.1161/CIRCULATIONAHA.109.868554
12. 2009 Specific role of neuronal nitric-oxide synthase when tethered to the plasma membrane calcium pump in regulating the beta-adrenergic signal in the myocardium J Biol Chem, 284(18), 12091-8. eScholarID:75758 | PMID:19278978 | DOI:10.1074/jbc.M809112200
13. 2007 The interaction between endogenous calcineurin and the plasma membrane calcium-dependent ATPase is isoform specific in breast cancer cells FEBS Lett, 581(21), 4115-9. eScholarID:75759 | PMID:17689535 | DOI:10.1016/j.febslet.2007.07.054
14. 2006 and neuronal nitric-oxide synthase are parts of a macromolecular protein complex J Biol Chem, 281(33), 23341-8. eScholarID:75760 | PMID:16735509 | DOI:10.1074/jbc.M513341200
15. 2005 Assessment of anthracyclin-related hyperlipidemia taurine or PDE4 inhibitor during endotoxemia Egyptian J Biochem Mol Biol, 23 (1), eScholarID:1d33299 | DOI:10.4314/ejbmb.v23i1.35912
16. 2004 Protection against doxorubicin cardiomyopathy in rats: role of phosphodiesterase inhibitors type 4 J Pharm Pharmacol, 56(6), 757-68. eScholarID:79052 | PMID:15231041 | DOI:10.1211/0022357023565
17. Three new cembrene diterpenoids, sarcoehrenbergilid A-C (1-3), along with four known diterpenoids, sarcophine (4), (+)-7α,8β-dihydroxydeepoxysarcophine (5), sinulolide A (6), and sinulolide B (7), and one steroid, sardisterol (8), were isolated and characterized from a solvent extract of the Red Sea soft coral Sarcophyton ehrenbergi. Pubmed Three new cembrene diterpenoids, sarcoehrenbergilid A-C (1-3), along with four known diterpenoids, sarcophine (4), (+)-7α,8β-dihydroxydeepoxysarcophine (5), sinulolide A (6), and sinulolide B (7), and one steroid, sardisterol (8), were isolated and characterized from a solvent extract of the Red Sea soft coral Sarcophyton ehrenbergi. Chemical structures were elucidated by NMR and MS analyses with absolute stereochemistry determined by X-ray analysis. Since these isolated cembrene diterpenes contained 10 or more carbons in a large flexible ring, conformer stabilities were examined based on density functional theory calculations. Anti-proliferative activities for 1-8 were evaluated against three human tumor cell lines of different origins including the: lung (A549), colon (Caco-2), and liver (HepG2). Sardisterol (8) was the most potent of the metabolites isolated with an IC50 of 27.3 µM against the A549 cell line. Since an elevated human-cancer occurrence is associated with an aberrant receptor function for the epidermal growth factor receptor (EGFR), molecular docking studies were used to examine preferential metabolite interactions/binding and probe the mode-of-action for metabolite-anti tumor activity. Sarcophyton ehrenbergi; cembranoids; cytotoxic activity; molecular docking; soft coral; terpenes

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