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Peer Reviewed Papers, Books, Chapters

Year Title Citation Authors Review type Summary Keywords File filename File mime type
1. 2012 Dopaminergic differentiation using pluripotent stem cells The Journal of Cellular Biochemistry. 2012. In Press.
2. 2012 Responses of human embryonic stem cells and their differentiated progeny to ionizing radiation. Biochem Biophys Res Commun. 2012 Aug 14. [Epub ahead of print]
3. 2012 Human neural crest stem cells derived from hESC and iPSC: Induction, maintenance and differentiation into functional Schwann cells. STEM CELLS TRANSLATIONALMEDICINE 2012;1:266–278.
4. 2012 Repair in Human Pluripotent Stem Cells is Distinct from that in Non-pluripotent Human Cells PLoS One. 2012;7(3):e30541
5. 2012 Scalable Production of Transplantable Dopaminergic Neurons from hESCs and iPSCs in Xeno-Free Conditions Current Protocols in Stem Cell Biology. In Press.
6. 2011 Endogenously EGFP-Labeled Mouse Embryonic Stem Cells Aging and Disease. 2011 February, 2(1): 1-17.
7. 2011 Dopaminergic neuronal differentiation of human embryonic stem cells A chapter in “Human Stem Cell Manual”, Edited by Jeanne F Loring. Academic Press. 2011. In Press
8. 2011 Neural and dopaminergic differentiation of human pluripotent stem cells Chapter 14 in “Stem Cells and CNS Development”. 2011. Edited by Mahendra Rao
9. 2011 The role of iPSCs in regenerative medicine: neurodegenerative diseases Stem Cell Research & Therapy. 2011, 2:32 (28 July 2011).
10. 2011 A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells J Cell Sci. 2011 Feb 1;124(Pt 3):348-58
11. 2011 Chromatin Insulator Elements Block Transgene Silencing in Engineered hESC Lines at a Defined Chromosome 13 Locus Stem Cells Dev. 2011 Jun 23. [Epub ahead of print].
12. 2010 Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions Stem Cells. 2010 Oct;28(10):1893-904
13. 2009 Xeno-free Defined Conditions for Culture of Human Embryonic Stem Cells, Neural Stem Cells and Dopaminergic Neurons Derived From Them PLoS One. 2009 Jul 14;4(7):e6233.
14. 2009 A targeted neuroglial reporter line generated by homologous recombination in human embryonic stem cells Stem Cells. 2009 May 14. [Epub ahead of print].
15. 2009 Stage-specific role for Shh in dopaminergic differentiation of human embryonic stem cells induced by stromal cells Stem Cells Dev. 2010 Jan;19(1):71-82
16. 2009 Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs and not dopaminergic neurons. PLoS One. 2009 Sep 23;4(9):e7155.
17. 2009 Future Directions: Use of intraoperative MRI for cell based therapy of Parkinson’s disease Neurosurg Clin N Am. 2009 Apr;20(2):211-8
18. 2008 Human Embryonic Stem Cells have Enhanced Repair of Multiple Forms of DNA Damage Stem Cells. 2008 Sep;26(9):2266-74.
19. 2008 Controlled genetic modification of stem cells for developing drug discovery tools and novel therapeutic applications Curr Opin Mol Ther. 2008 Jun;10(3):207-13.
20. 2008 Gene Expression Profile of Neuronal Progenitor Cells Derived from hESC: Activation of Chromosome 11p15.5 and Comparison to Human Dopaminergic Neurons PLoS ONE. 2008 Jan 9;3(1):e1422.
21. 2007 Generation and transplantation of dopaminergic neurons derived from embryonic stem cells Current Stem Cell Research & Therapy. 2007,2, 139-147
22. 2007 A Large-scale Proteomic Analysis of Human Embryonic Stem Cells BMC Genomics. 2007 Dec 27;8:478
23. 2007 Human Embryonic Stem Cells, Dopaminergic Neurons, and Pathways for Developing a Parkinson’s Disease Therapy. Chapter 30 Cellular Transplants: From Lab to Clinic”. 2007; 523-544
24. 2007 Human embryonic stem cells: Long term stability, absence of senescence and potential cell sources for neural replacement Neuroscience. 2007 Apr 14;145(4):1348-58
25. 2007 Human embryonic stem cells: Mechanisms to escape replicative senescence? Stem Cell Rev. 2007 Dec;3(4):270-9.
26. 2006 A molecular scheme for improved characterization of human embryonic stem cell lines BMC Biol. 2006 Aug 18;4:28
27. 2006 An in vitro model of human dopaminergic neurons derived from embryonic stem cells: MPP+ toxicity and GDNF neuroprotection Neuropsychopharmacology. 2006 Dec;31(12):2708-2715
28. 2006 Assessing self-renewal and differentiation in hESC lines Stem Cells. 2006 Mar;24(3):516-30
29. 2006 Derivation and characterization of neuronal precursors and dopaminergic neurons from hESCs in vitro Methods Mol Biol. 2006;331:153-67
30. 2006 The therapeutic potential of embryonic stem cells: Stem cell stability Curr Opin Mol Ther. 2006 Aug;8(4):338-44
31. 2006 Characterization of a New NIH Registered Variant Human Embryonic Stem Cell Line BG01V: A Tool for Human Embryonic Stem Cell Research. Stem Cells. 2006 Mar;24(3):531-46
32. 2006 A focused microarray to assess dopaminergic and glial cell differentiation from fetal tissue or embryonic stem cells Stem Cells. 2006 Apr;24(4):865-75.
33. 2006 GABAergic lineage differentiation of AF5 neural progenitor cells in vitro Cell Tissue Res. 2006 Apr;324(1):1-8
34. 2006 Genome wide profiling of hESC, EC and their progenies using bead arrays to develop a base profile of gene expression of pre-August 9th human ES cell lines BMC Dev Biol. 2006 May 3;6:20
35. 2005 Development of a focused microarray to assess human embryonic stem cell differentiation. Stem Cells Dev. 2005 Jun;14(3):270-84
36. 2005 NTera2: a model system to study dopaminergic differentiation of human embryonic stem cells. Stem Cells Dev. 2005 Oct;14(5):517-534
37. 2005 Comparison of the Gene Expression Profile of Undifferentiated Human Embryonic Stem Cell lines and Embryoid Bodies differentiated from them BMC Dev Biol. 2005 Oct 5;5(1):22.
38. 2005 Monitoring differentiation of human embryonic stem cells using real-time PCR Stem Cells. 2005;23:1460-1467.
39. 2005 Genomic alternations in cultured human embryonic stem cells Nat Genet. 2005 Oct;37(10):1099-1103.
40. 2004 Absence of DNA polymerase h reveals targeting of C mutations on the non-transcribed strand in Immunoglobulin switch regions J Exp Med. 2004 Apr 5;199(7):917-24.
41. 2004 A variant hESC line which exhibits rapid growth after passaging and reliable dopaminergic differentiation Restor Neurol Neurosci. 2004;22(6):421-8
42. 2004 Karyotypic stability, genotyping, differentiation, feeder free maintenance and gene expression sampling in three human embryonic stem cell lines derived prior to August 9th 2001 Stem Cells and Development. Dec 2004, Vol. 13, No. 6: 585-597
43. 2004 Dopaminergic Differentiation of Human Embryonic Stem Cells Stem Cells 2004; 22: 925-940
44. 2004 Properties of Pluripotent Human Embryonic Stem Cells BG01 and BG02 Stem Cells. 2004;22(3):292-312
45. 2003 Stable Expression of hrGFP by Mouse Embryonic Stem Cells: Promoter Activity in the Undifferentiated State and during Dopaminergic Neural Differentiation Stem Cells. 2003;21(6):647-53
46. 2003 Normal Somatic Hypermutation of Ig Genes in the Absence of 8-Hydroxyguanine-DNA Glycosylase J Immunol. 2003 Jun 1;170(11):5558-62.
47. 2002 Colocalization, physical and functional interaction between Werner and Bloom syndrome proteins. J Biol Chem. 2002 Jun 14;277(24):22035-44
48. 2002 Functional crosstalk between hOGG1 and the helicase domain of Cockayne syndrome group B protein DNA Repair (Amst). 2002 Nov 3;1(11):913-27.
49. 2001 DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes. Nature Immunology. 2001 Jun;2(6):537-41.
50. 2001 Altered nucleotide misinsertion fidelity associated with poli-dependent replication at the end of a DNA template EMBO J. 2001 Jun 1;20(11):2914-22.
51. 2000 Purification and characterization of the DeoR repressor of Bacillus subtilis. J Bacteriol. 2000 Apr;182(7):1916-22
52. 2000 Characterization of catabolite repression of the dra-nupC-pdp operon expression in Bacillus subtilis. Microbiology. 2000 Nov;146 ( Pt 11):2901-8
53. 1999 Identification and characterization of a DeoR-specific operator sequence essential for induction of dra-nupC-pdp operon expression in Bacillus subtilis J Bacteriol. 1999 Mar;181(6):1719-27.
54. INTRODUCTION: MicroRNA-155 (miR-155) is an oncogenic microRNA, which is upregulated in many human cancers including colorectal cancer (CRC). Pubmed INTRODUCTION: MicroRNA-155 (miR-155) is an oncogenic microRNA, which is upregulated in many human cancers including colorectal cancer (CRC). Overexpression of miR-155 has been found to regulate several cancer-related pathways, and therefore, targeting miR-155 may be an effective strategy for cancer therapy. However, effective and safe delivery of anti-miR-155 to tumors remains challenging for the clinical applications of anti-miR-155-based therapeutics. METHODS: In this study, we explored the expression of miR-155 and the transcription factor nuclear factor kappa B (NF-κB) in CRC tissues and cell lines, and the possible relationship between miR-155 and NF-κB. We further report on anti-miR-155-loaded mesoporous silica nanoparticles (MSNs) modified with polymerized dopamine (PDA) and AS1411 aptamer (MSNs-anti-miR-155@PDA-Apt) for the targeted treatment of CRC. RESULTS: Results showed that miR-155 is overexpressed in CRC tissues and cell lines, and there is a positive feedback loop between NF-κB and miR-155. Compared to the control groups, MSNs-anti-miR-155@PDA-Apt could efficiently downregulate miR-155 expression in SW480 cells and achieve significantly high targeting efficiency and enhanced therapeutic effects in both in vivo and in vitro experiments. Furthermore, inhibition of miR-155 by MSNs-anti-miR-155@PDA-Apt can enhance the sensitivity of SW480 to 5-fluorouracil chemotherapy. CONCLUSION: Thus, our results suggested that MSNs-anti-miR-155@PDA-Apt is a promising nanoformulation for CRC treatment. 5-fluorouracil; AS1411 aptamer; NF-κB; mesoporous silica nanoparticles; miR-155

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